Pharmaceutical formulations containing lipoic acid derivatives
The invention provides a method of treating leukemia using a pharmaceutical composition containing bis-benzyl lipoate, triethanolamine, and a pharmaceutically acceptable diluent, where the bis-benzyl lipoate and triethanolamine form an ion pair.
1. A method of treating leukemia, comprising administering to a patient in need thereof to treat the leukemia a therapeutically effective amount of a pharmaceutical formulation comprising:
(a) a compound of Formula I:
(b) triethanolamine; and
(c) a pharmaceutically acceptable diluent;
wherein the compound of Formula I and triethanolamine form an ion pair.
2. The method of claim 1 , wherein the diluent is selected from the group consisting of saline, a sugar solution, an alcohol, dimethylformamide, dimethylsulfoxide, dimethylacetamide, and combinations thereof.
3. The method of claim 1 , wherein the diluent is a dextrose solution.
4. The method of claim 3 , wherein the dextrose solution contains an amount of dextrose ranging from about 2.5% to about 10% by weight.