Inhibitors of Akt activity

1. A compound according to Formula A:

wherein:

is

each R 1 , R 1′ , R 1″ and R 1′″ is independently selected from: H, oxo, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, (C═O) a O b (C 2 -C 10 )alkenyl, (C═O) a O b (C 2 -C 10 )alkynyl, CO 2 H, halo, OH, O b (C 1 -C 6 )perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b (C 3 -C 8 )cycloalkyl, S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl and (C═O) a O b -heterocyclyl, said alkyl, aryl, alkenyl, alkenyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

Bond: is a single or double bond, provided that when each R 1 , R 1′ , R 1″ and R 1′″ is oxo, then said bond adjacent to the oxo is a single bond and C or N which is attached to the resulting carbonyl with said single bond bears H;

a is 0 or 1; b is 0 or 1; m is 0, 1 or 2; p is independently 0, 1, 2, 3, 4 or 5;

Ring Z is selected from: (C 3 -C 8 )cycloalkyl, aryl, and heterocyclyl;

R 2 is independently selected from: oxo, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, (C═O) a O b (C 2 -C 10 )alkenyl, (C═O) a O b (C 2 -C 10 )alkynyl, CO 2 H, halo, OH, O b (C 1 -C 6 )perfluoroalkyl, (C═O) a NR 7 R 8 , CN, (C═O) a O b (C 3 -C 8 )cycloalkyl, S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl and (C═O) a O b -heterocyclyl, said alkyl, aryl, alkenyl, alkynyl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 6 is: (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b aryl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C═O) a O b heterocyclyl, CO 2 H, halo, CN, OH, O b (C 1 -C 6 )perfluoroalkyl, O a (C═O) b NR 7 R 8 , oxo, CHO, (N═O)R 7 R 8 , S(O) m NR 7 R 8 , SH, S(O) m —(C 1 -C 10 )alkyl or (C═O) a O b (C 3 -C 8 )cycloalkyl, said alkyl, aryl, alkenyl, alkynyl, heterocyclyl, and cycloalkyl optionally substituted with one or more substituents selected from R 6a ;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, (C 0 -C 6 )alkylene-S(O) m R a , SH, oxo, OH, halo, CN, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, (C 3 -C 6 )cycloalkyl, (C 0 -C 6 )alkylene-aryl, (C 0 -C 6 )alkylene-heterocyclyl, (C 0 -C 6 )alkylene-N(Rb) 2 , C(O)R a , (C 0 -C 6 )alkylene-CO 2 R a , C(O)H, (C═O) a NR b 2 , and (C 0 -C 6 )alkylene-CO 2 H, said alkyl, alkenyl, alkynyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with up to three substituents selected from R b , OH, halogen, CO 2 H, CN, O a (C═O) b (C 1 -C 6 )alkyl, oxo, and N(Rb) 2 ;

R 7 and R 8 are independently selected from: H, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b (C 3 -C 8 )cycloalkyl, (C═O) a O b -aryl, (C═O) a O b -heterocyclyl, (C 2 -C 10 )alkenyl, (C 2 -C 10 )alkynyl, SH, SO 2 R a , and (C═O) a NR b 2 , said alkyl, cycloalkyl, aryl, heterocyclyl, alkenyl, and alkynyl is optionally substituted with one or more substituents selected from R 6a , or R 7 and R 8 can be taken together with the nitrogen to which they are attached to form a monocyclic, bicyclic or tricyclic heterocycle with 3-7 members in each ring and optionally containing, in addition to the nitrogen, one or two additional heteroatoms selected from N, O and S, said monocyclic, bicyclic or tricyclic heterocycle is optionally substituted with one or more substituents selected from R 6a ;

R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl, said alkyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with one or more substituents selected from R c ;

R b is independently: H, (C═O) a O b (C 1 -C 6 )alkyl, (C 2 -C 10 )alkenyl, S(O) m R a , (C═O) a NR d 2 , (C═O) a R a , or S(O) m NR e 2 , said alkyl and alkenyl is optionally substituted with one or more substituents selected from R a , (C═O) a O b (C 1 -C 6 )alkyl, OH, halo, CN, CO 2 H, and (C═O) a NR d 2 ;

R c is independently: (C═O) a O b (C 1 -C 6 )alkyl, aryl, heterocyclyl, (C 3 -C 6 )cycloalkyl, oxo, OH, halo, CN, (C═O) a NR d 2 , or S(O) m R d , said alkyl, aryl, heterocyclyl, and cycloalkyl is optionally substituted with one or more substituents selected from (C═O) a O b (C 1 -C 6 )alkyl, O a (C 1 -C 3 )perfluoroalkyl, OH, halo, and CN;

R d is independently: H, (C═O) a O b (C 1 -C 6 )alkyl, aryl, or S(O) m R e , said alkyl and aryl is optionally substituted with one or more substituents selected from (C═O) a O b (C 1 -C 6 )alkyl, OH, halo, and CN;

R e is independently: H, or (C 1 -C 6 )alkyl; and

R x and R y are independently selected from: H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, and (C 2 -C 6 )alkynyl, wherein said alkyl is optionally substituted with up to three substituents selected from: OH and halo, or R x and R y can be taken together to form a monocyclic or bicyclic carbo- or heterocycle with 3-7 members in each ring, said heterocycle is containing one or more heteroatoms selected from N, O and S, and said carbo- or heterocycle is optionally substituted with one or more substituents selected from: (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkylidene, (C 1 -C 6 )alkoxy, CO 2 H, halo, OH, oxo, CN and NR 7 R 8 , said alkyl, cycloalkyl and alkoxy is optionally substituted with one or more substituents selected from halo, CN, OH and NR 7 R 8 ;

or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.

2. A compound according to claim 1 of Formula C:

wherein:

I is CH;

a is 0 or 1; b is 0 or 1;

Ring X is selected from:

each of which is optionally substituted with one or more substituents selected from R 6a ;

R 1 is selected from: H, oxo, (C═O) a O b (C 1 -C 10 )alkyl, OH, and (C═O) a O b -heterocyclyl;

R 6a is selected from: (C═O) a O b (C 1 -C 10 )alkyl, oxo, OH, halo, (C 0 -C 6 )alkylene-heterocyclyl, and (C═O) a NR b 2 , said alkyl, and heterocyclyl is optionally substituted with up to three substituents selected from R b ;

R a is (C 1 -C 6 )alkyl, (C 3 -C 6 )cycloalkyl, aryl, or heterocyclyl, said alkyl, cycloalkyl, aryl, and heterocyclyl is optionally substituted with one or more substituents selected from R c ;

R b is independently: H, (C═O) a O b (C 1 -C 6 )alkyl, or (C═O) a R a , said alkyl is optionally substituted with one or more substituents selected from (C═O) a O b (C 1 -C 6 )alkyl, OH, halo, CN, and (C═O) a NR d 2 ;

R c is independently: (C═O) a O b (C 1 -C 6 )alkyl, oxo, OH, halo, CN, or (C═O) a NR d 2 , said alkyl is optionally substituted with one or more substituents selected from (C 1 -C 6 )alkyl, OH, halo, and CN;

R d is independently: H, or (C 1 -C 6 )alkyl; and

Bond: is a single or double bond, provided that when R 1 is oxo, then said bond is a single bond and adjacent N bears H;

or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.

3. A compound according to claim 1 of Formula D:

wherein:

a is 0 or 1; b is 0 or 1;

Ring Y is a group of formula:

R 1 is selected from: H, oxo, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, OH, (C═O) a O b (C 3 -C 8 )cycloalkyl, and (C═O) a O b -heterocyclyl, said alkyl, aryl, cycloalkyl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 1′ is selected from: H, (C═O) a O b (C 1 -C 10 )alkyl, (C═O) a O b -aryl, halo, CN and (C═O) a O b -heterocyclyl, said alkyl, aryl, and heterocyclyl is optionally substituted with one or more substituents selected from R 6 ;

R 6 is: (C═O) a O b (C 1 -C 10 )alkyl, halo or OH;

R 7 and R 8 are independently selected from: H, and (C 1 -C 6 )alkyl;

R 11 and R 12 are independently selected from: H, (C 1 -C 6 )alkyl, (C 2 -C 6 )alkenyl, (C 3 -C 6 )cycloalkyl, (C 1 -C 6 )alkoxy, CO 2 H, halo, OH, CN and NR 7 R 8 , said alkyl, cycloalkyl and alkoxy is optionally substituted with one or more substituents selected from halo, CN, OH and NR 7 R 8 , or R 11 and R 12 can be taken together to form oxo, (C 1 -C 6 )alkylidene, or a monocyclic carbo- or heterocycle with 3-7 members, said heterocycle is containing one or more heteroatoms selected from N, O and S; and

Bond: is a single or double bond, provided that when R 1 is oxo, then said bond is a single bond and adjacent N bears H;

or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.

4. A compound of claim 1 selected from:

trans-3-amino-1-methyl-3-[4-(2-methyl-7-phenylpyrazolo [1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

cis-3-amino-1-methyl-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-1-cyclopropyl-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-methoxy-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanamine;

methyl {1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-3-oxocyclobutyl}carbamate;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]methanamine;

2-methyl-7-phenyl-8-[4-(1H-pyrazol-1-ylmethyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

(1R)-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]ethanamine;

trans-3-amino-1-ethyl-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

cis-3-amino-1-ethyl-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-1-ethenyl-3-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

3-methylidene-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanamine;

3,3-difluoro-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanamine;

8-{4-[trans-1-amino-3-(1,2-dihydroxyethyl)-3-hydroxycyclobutyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[1-amino-3-hydroxy-3-(hydroxymethyl)cyclobutyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-5,8-dioxaspiro[3.4]octan-2-amine;

cis-3-amino-1-cyclopropyl-3-[4-(2-cyclopropyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-1-cyclopropyl-3-[4-(7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

8-[4-(trans-1-amino-3-cyclopropyl-3-hydroxycyclobutyl)phenyl]-7-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

trans-3-cyclopropyl-1-{4-[2-(4-fluorophenyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}-3-hydroxycyclobutanamine;

trans-1-[4-(2-cyclopropyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-3-hydroxy-3-methylcyclobutanamine;

trans-3-amino-3-[4-[2-(1,1-dimethylethyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl]-1-methyl-cyclobutanol;

trans-3-amino-1-methyl-3-{4-[2-methyl-7-(thiophen-2-yl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}cyclobutanol;

trans-3-amino-3-{4-[7-(2-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}-1-methylcyclobutanol;

trans-3-amino-1-methyl-3-{4-[2-methyl-7-(thiophen-3-yl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}cyclobutanol;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanamine;

2-methyl-7-phenyl-8-(4-{[4-(5-pyridin-2-yl-4H-1,2,4-triazol-3-yl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

1′-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-1H-spiro[furo[3,4-c]pyridine-3,4′-piperidin]-1-one;

2-methyl-1′-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]spiro[isoindole-1,4′-piperidin]-3(2H)-one;

1′-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-7H-spiro[furo[3,4-b]pyridine-5,4′-piperidin]-7-one;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

2-methyl-8-(4-{[4-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)piperidin-1-yl]methyl}phenyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-[4-(piperazin-1-ylmethyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-8-{4-[(4-methylpiperazin-1-yl)methyl]phenyl}-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

N-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-2-(1-methylpyrrolidin-2-yl)ethanamine;

2-methyl-8-[4-(morpholin-4-ylmethyl)phenyl]-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

3-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}phenol;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-ol;

2-methyl-7-phenyl-8-[4-(piperidin-1-ylmethyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

1-{4-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperazin-1-yl}ethanone;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-amine;

1-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one;

4-hydroxy-N-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}benzamide;

ethyl 1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxylate;

methyl 1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxylate;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxylic acid;

2-methyl-7-phenyl-8-(4-{[4-(phenylcarbamoyl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(2-methoxyethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-(4-{[4-(prop-2-en-1-ylcarbamoyl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[2-(dimethylamino)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[3-(1H-imidazol-1-yl)propyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3,4-dimethoxybenzyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-8-{4-[(4-{[2-(1-methylpyrrolidin-2-yl)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}(morpholin-4-yl)methanone;

8-[4-({4-[(1H-benzimidazol-2-ylmethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

N-[2-(1H-imidazol-5-yl)ethyl]-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

2-methyl-7-phenyl-8-{4-[(4-{[4-(pyrimidin-2-yl)piperazin-1-yl]carbonyl}piperidin-1-yl)methyl]phenyl}pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-(4-{[4-({4-[5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}carbonyl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-{4-[(4-{[4-(pyridin-2-yl)piperazin-1-yl]carbonyl}piperidin-1-yl)methyl]phenyl}pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-{4-[(4-{[2-(pyridin-3-yl)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-[4-({4-[(pyridin-2-ylmethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-[4-({4-[(pyridin-4-ylmethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-hydroxyphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(trans-4-hydroxycyclohexyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[2-hydroxy-2-(3-hydroxyphenyl)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[2-(4-hydroxyphenyl)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-hydroxy-4-methoxyphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[2-(3,4-dihydroxyphenyl)ethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(4-hydroxy-3-methoxybenzyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3,4-dihydroxybenzyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(benzylcarbamoyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[benzyl(methyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(cyclohexylcarbamoyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(1-methoxypropan-2-yl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

N-({1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}carbonyl)glycinamide;

2-methyl-7-phenyl-8-[4-({4-[(2,2,2-trifluoroethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-8-(4-{[4-(pentan-3-ylcarbamoyl)piperidin-1-yl]methyl}phenyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(tert-butylcarbamoyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-(4-{[4-(propylcarbamoyl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-8-(4-{[4-(methylcarbamoyl)piperidin-1-yl]methyl}phenyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(ethylcarbamoyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[4-(3-hydroxyphenyl)piperazin-1-yl]carbonyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[(1S)-1-cyclohexylethyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(hexahydrocyclopenta[c]pyrrol-2(1H)-ylcarbonyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[ethyl(propan-2-yl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-{4-[(4-{[(1S,2S)-2-hydroxycyclohexyl]carbamoyl}piperidin-1-yl)methyl]phenyl}-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(2-hydroxyethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-[4-({4-[(tetrahydrofuran-2-ylmethyl)carbamoyl]piperidin-1-yl}methyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-(4-{[4-(cyclobutylcarbamoyl)piperidin-1-yl]methyl}phenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-(4-{[4-(propan-2-ylcarbamoyl)piperidin-1-yl]methyl}phenyl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

N-({1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}carbonyl)glycine;

tert-butyl N-({1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}carbonyl)glycinate;

8-[4-({4-[(4-hydroxyphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-carbamoylphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-methoxyphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-8-(4-{[4-({3-[(methylsulfonyl)amino]phenyl}carbamoyl)piperidin-1-yl]methyl}phenyl)-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-cyanophenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(3-fluorophenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(2-hydroxyphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

8-[4-({4-[(4-carbamoylphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

2-methyl-7-phenyl-8-[4-({4-[(3-sulfamoylphenyl)carbamoyl]piperidin-1-yl}methyl)phenyl]pyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

N-(1,1-dioxido-1-benzothiophen-6-yl)-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

3-aminobenzyl 1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxylate;

{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}(piperidin-1-yl)methanone;

(1,1-dioxidothiomorpholin-4-yl) {1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}methanone;

1-[4-({1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}carbonyl)piperazin-1-yl]ethanone;

N-(3-chlorophenyl)-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

(4-hydroxypiperidin-1-yl) {1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}methanone;

N-cyclohexyl-N-methyl-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

[4-(hydroxymethyl)piperidin-1-yl] {1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}methanone;

4-tert-butyl-N-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}benzamide;

1-(4-fluorophenyl)-3-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}urea;

1-(4-tert-butylphenyl)-3-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}urea;

N-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}benzamide;

1-{1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidin-4-yl}-3-phenylurea;

N-(3-aminophenyl)-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

N-[3-(hydroxymethyl)phenyl]-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-N-[3-(methylsulfonyl)phenyl]piperidine-4-carboxamide;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-N-(3-oxo-1,3-dihydro-2-benzofuran-5-yl)piperidine-4-carboxamide;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-N-(1,3-thiazol-2-yl)piperidine-4-carboxamide;

1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]-N-[3-(trifluoromethoxy)phenyl]piperidine-4-carboxamide;

N-(1,3-benzothiazol-5-yl)-1-[4-(2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)benzyl]piperidine-4-carboxamide;

trans-3-amino-1-cyclopropyl-3-[4-(3-bromo-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-3-[4-(3-chloro-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-1-cyclopropylcyclobutanol;

trans-3-amino-1-cyclopropyl-3-{4-[2-methyl-7-phenyl-3-(pyridin-3-yl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}cyclobutanol;

trans-3-amino-1-cyclopropyl-3-[4-(3-cyano-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-1-cyclopropyl-3-{4-[2-methyl-7-phenyl-3-(pyridin-4-yl)pyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}cyclobutanol;

trans-3-amino-1-cyclopropyl-3-[4-(2-methyl-3,7-diphenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]cyclobutanol;

trans-3-amino-1-cyclopropyl-3-{4-[3-(4-methoxyphenyl)-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl]phenyl}cyclobutanol;

8-[4-(trans-1-amino-3-cyclopropyl-3-hydroxycyclobutyl)phenyl]-2,3-dimethyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidine;

trans-3-amino-3-[4-(2,5-dimethyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-1-methylcyclobutanol;

trans-3-amino-3-[4-(2,6-dimethyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-1-methylcyclobutanol;

trans-3-amino-3-[4-(6-chloro-2-methyl-7-phenylpyrazolo[1,5-a]pyrido[3,2-e]pyrimidin-8-yl)phenyl]-1-methylcyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutylamine;

3,3-Difluoro-1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutylamine;

trans-2-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-5,8-dioxa-spiro[3.4]oct-2-ylamine;

trans-3-Amino-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-1-Amino-1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-3-methoxycyclobutane;

1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-ethane-1,2-diol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

cis-3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-cyclopropyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-(4-fluorophenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-trifluoromethyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

2-Methyl-8-(4-morpholin-4-ylmethyl-phenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenylamine;

N-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-methanesulfonamide;

[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-urea;

Morpholine-4-carboxylic acid [4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-amide;

3-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-oxazolidin-2-one;

4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzylamine;

[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-methanol;

1′-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenylmethyl]-Spiro[furo [3,4-c]pyridine-3(1H),4′-piperidine]-1-one;

1′-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenylmethyl]-spiro[2-methyl-2,3-dihydro-isoindole-3(1H), 4′-piperidine]-1-one;

1′-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenylmethyl]-spiro[furo [3,4-b]pyridine-5(7H), 4′-piperidine]-7-one;

8-[4-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-ylmethyl)-phenyl]-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid amide;

3-[4-(2-Methyl-7-phenyl-3-pyridin-3-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-oxazolidin-2-one;

trans-3-Amino-1-cyclopropyl-3-[4-(3-cyano-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

3-Amino-3-[4-(3-bromo-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclopropyl-cyclobutanol;

3-Amino-3-[4-(3-chloro-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclopropyl-cyclobutanol;

3-Amino-3-[4-(2,5-dimethyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-methyl-cyclobutanol;

3-Amino-1-methyl-3-[4-(2-methyl-7-thiophen-2-yl-8,9-dihydro-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene-8-yl)-phenyl]-cyclobutanol;

3-Amino-1-methyl-3-[4-(2-methyl-7-thiophen-3-yl-8,9-dihydro-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene-8-yl)-phenyl]-cyclobutanol;

3-Amino-3-{4-[7-(2-fluoro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

3-Amino-1-hydroxymethyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

3-Methylene-1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutylamine;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanecarbonitrile;

Methyl-{1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutyl}-amine;

1-Cyclopropyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

Trans-3-Amino-1-ethyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

Cis-3-Amino-1-ethyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

Trans-1-{3-Amino-1-hydroxy-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutyl}-ethane-1,2-diol;

Trans-3-Amino-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-vinyl-cyclobutanol;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid ethyl ester;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid phenylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid allylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-dimethylamino-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-methoxy-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-imidazol-1-yl-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid 3,4-dimethoxy-benzylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid [2-(1-methyl-pyrrolidin-2-yl)-ethyl]-amide;

{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-morpholin-4-yl-methanone;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (1H-benzoimidazol-2-ylmethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid [2-(3H-imidazol-4-yl)-ethyl]-amide;

{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-(4-pyrimidin-2-yl-piperazin-1-yl)-methanone;

{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-[4-(5-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-methanone;

{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-(4-pyridin-2-yl-piperazin-1-yl)-methanone;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-pyridin-3-yl-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (pyridin-2-ylmethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (pyridin-4-ylmethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-hydroxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (4-hydroxy-cyclohexyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid [2-hydroxy-2-(3-hydroxy-phenyl)-ethyl]-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid [2-(4-hydroxy-phenyl)-ethyl]-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-hydroxy-4-methoxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid [2-(3,4-dihydroxy-phenyl)-ethyl]-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid 4-hydroxy-3-methoxy-benzylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid benzylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid benzyl-methyl-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid cyclohexylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-methoxy-1-methyl-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid carbamoylmethyl-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2,2,2-trifluoro-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (1-ethyl-propyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid tert-butylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid propylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid methylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid ethylamide;

[4-(3-Hydroxy-phenyl)-piperazin-1-yl]-{1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-methanone;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid ((S)-1-cyclohexyl-ethyl)-amide;

(Hexahydro-cyclopenta[c]pyrrol-2-yl)-{1-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-methanone;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid ethyl-isopropyl-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid ((1S,2S)-2-hydroxy-cyclohexyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-hydroxy-ethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (tetrahydro-furan-2-ylmethyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid cyclobutylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid isopropylamide;

({1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carbonyl}-amino)-acetic acid;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (4-hydroxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-carbamoyl-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-methoxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-methanesulfonylamino-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-cyano-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-fluoro-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-hydroxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (4-carbamoyl-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-sulfamoyl-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid benzothiazol-5-ylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-trifluoromethoxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid thiazol-2-ylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-methanesulfonyl-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-hydroxymethyl-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid 3-amino-benzyl ester;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (3-amino-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (1,1-dioxo-1H-1-benzo[b]thiophen-6-yl)amide;

3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-t-butyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

3-Amino-1-cyclopropyl-3-[4-(2,3-dimethyl-7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-Methyl-3-[4-(2-cyclopropyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

3-Amino-3-[4-(6-chloro-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

3-Amino-3-[4-(2,6-dimethyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-(4-methoxyphenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-isopropyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-cyclobutyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

3-Amino-1-methyl-3-[4-(7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-(pyridine-4-yl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-(thiophen-3-yl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

2-Methyl-7-phenyl-8-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraazacyclopenta[a]naphthalene;

2-Methyl-8-(4-{4-[5-(4-methylpyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-7-phenyl-1,4,9,9b-tetraazacyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-(4-{4-[5-(2-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

4-(5-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-4H-[1,2,4]triazol-3-yl)-benzamide;

2-Methyl-7-phenyl-8-(4-{4-[5-(3-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-{4-[4-(5-pyridin-3-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-(4-{4-[5-(4-trifluoromethyl-phenyl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-8-{4-[4-(5-phenoxymethyl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-8-(4-{4-[5-(3-methyl-pyridin-2-yl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

8-(4-{4-[5-(3-Methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

8-(4-{4-[5-(4-Methoxy-phenyl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-{4-[4-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-{4-[4-(5-pyridin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-{4-[4-(5-pyridin-4-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-8-(4-{4-[5-(4-methyl-pyridin-2-yl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-{4-[4-(5-pyrimidin-2-yl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-7-phenyl-8-(4-{4-[5-(6-trifluoromethyl-pyridin-3-yl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

2-Methyl-8-(4-{4-[5-(6-methyl-pyridin-2-yl)-4H-[1,2,4]triazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

1-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one;

2-Methyl-8-{4-[4-(4-methyl-4H-[1,2,4]triazol-3-yl)-piperidin-1-ylmethyl]-phenyl}-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

8-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-1,3,8-triaza-spiro[4.5]decane-2,4-dione;

8-(4-{4-[5-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-piperidin-1-ylmethyl}-phenyl)-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene;

{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-carbamic acid tert-butyl ester;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-ylamine;

N-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-isonicotinamide;

N-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-phthalamic acid;

1-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-3-pyridin-4-yl-urea;

1-{1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidin-4-yl}-N-morpholinyl-urea;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid pyridin-4-ylamide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (2-methoxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid (4-carbamoyl-2-methoxy-phenyl)-amide;

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid hydrazide trans-3-Amino-3-[4-(2-tert-butyl-7-(thiophen-2-yl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[2-tert-butyl-7-(2-fluoro-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(2-tert-butyl-7-(thiophen-3-yl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(7-phenyl-4,5-dihydro-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(5-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(7-thiophen-2-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-methyl-3,7-diphenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-{4-[3-(4-methoxy-phenyl)-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2-methyl-7-phenyl-3-pyridin-4-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-ethyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(3-bromo-2-methyl-7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-cyclopropyl-3-[4-(2,3-dimethyl-7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-6,7-diphenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-6-ol;

trans-3-Amino-3-[4-(6-cyclopropyl-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(2-isopropyl-7-thiophen-3-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4(2-isopropyl-7-thiophen-2-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(2-fluoro-phenyl)-2-isopropyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(2-cyclopropyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-isopropyl-cyclobutanol;

trans-3-Amino-1-isopropyl-3-[4-(2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

cis-3-Amino-3-[4-(2-cyclopropyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-isopropyl-cyclobutanol;

trans-2-{1-[4-(2-cyclopropyl-5-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-3-hydroxy-3-methyl-cyclobutyl}-isoindole-1,3-dione;

trans-3-Amino-3-[4-(2-isopropyl-5-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(3-fluoro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(4-fluoro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(4-chloro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(3-chloro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-o-tolyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-3-{4-[7-(2-methoxy-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(3-methoxy-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-3-{4-[7-(2-chloro-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-m-tolyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-3-{4-[7-(4-methoxy-phenyl)-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-1-methyl-cyclobutanol;

trans-3-Amino-1-methyl-3-{4-[2-methyl-7-(2-trifluoromethyl-phenyl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-pyridin-3-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-{8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-benzonitrile;

trans-2-{8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-benzonitrile;

trans-4-{8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-benzonitrile;

4-{8-[4-(1-amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-phenyl ester;

trans-4-{8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-phenol;

trans-3-{8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-phenol;

3-{8-[4-(1-amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-phenyl ester;

2-{8-[4-(1-amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-7-yl}-phenyl ester;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-pyridin-4-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-6-pyridin-3-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-6-pyridin-4-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-[4-(2-methyl-7-phenyl-6-pyrimidin-5-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-1-methyl-3-{4-[2-methyl-7-phenyl-6-(1H-pyrazol-3-yl)-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl]-phenyl}-cyclobutanol;

trans-8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene-6-carbonitrile;

trans-3-Amino-3-[4-(6-methoxy-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(6-amino-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(3-bromo-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-2-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene-3-carbonitrile;

trans-8-[4-(1-Amino-3-hydroxy-3-methyl-cyclobutyl)-phenyl]-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalene-3-carbonitrile;

trans-3-Amino-1-methyl-3-[4-(3-methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol;

trans-3-Amino-3-[4(2-isopropenyl-7-phenyl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4-(2-cyclopropyl-7-thiophen-2-yl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

trans-3-Amino-3-[4(2-isopropenyl-7-thiophen-2-yl-1,4,6,9,9b-pentaaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-1-methyl-cyclobutanol;

3-Amino-1-methyl-3-[4-(2,5,6-trimethyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-phenyl]-cyclobutanol; and

1-[4-(2-Methyl-7-phenyl-1,4,9,9b-tetraaza-cyclopenta[a]naphthalen-8-yl)-benzyl]-piperidine-4-carboxylic acid methyl ester;

or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.

5. A pharmaceutical composition comprising a pharmaceutical carrier, and dispersed therein, a therapeutically effective amount of the compound according to claim 1 or a pharmaceutically acceptable salt, stereoisomer or N-oxide derivative thereof.