Inhibitors of PI3 kinase
The present invention relates to compounds of Formula I, II or III or a pharmaceutically acceptable salt thereof; methods of treating diseases or conditions, such as cancer, using the compounds; and pharmaceutical compositions containing the compounds, wherein the variables are as defined herein.
1. A compound, or a pharmaceutically acceptable salt thereof, selected from:
4-fluoro-N-(5-imidazo[1,2-a]pyridin-3-yl-3-pyridinyl)benzenesulfonamide;
N-(2-chloro-5-imidazo[1,2-a]pyridin-3-yl-3-pyridinyl)-4-fluorobenzenesulfonamide;
N-(2-chloro-5-(7-methylimidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide;
N-(5-(6-bromoimidazo[1,2-a]pyridin-3-yl)-2-chloro-3-pyridinyl)-4-fluorobenzenesulfonamide;
N-(2-chloro-5-(6-(4-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide;
N-(2-chloro-5-(6-(3-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide;
N-(2-chloro-5-(6-(4-morpholinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-4-fluorobenzenesulfonamide;
3-(5,6-dimethoxy-3-pyridinyl)imidazo[1,2-a]pyridine;
6-bromo-3-(5,6-dimethoxy-3-pyridinyl)imidazo[1,2-a]pyridine;
3-(5,6-dimethoxy-3-pyridinyl)-6-(4-pyridinyl)imidazo[1,2-a]pyridine;
3-(3-(5,6-dimethoxy-3-pyridinyl)imidazo[1,2-a]pyridin-6-yl)-1,3-oxazolidin-2-one;
(4R)-4-benzyl-3-(3-(5,6-dimethoxy-3-pyridinyl)imidazo[1,2-a]pyridin-6-yl)-1,3-oxazolidin-2-one;
(4S)-4-benzyl-3-(3-(5,6-dimethoxy-3-pyridinyl)imidazo[1,2-a]pyridin-6-yl)-1,3-oxazolidin-2-one;
3-(5,6-dimethoxy-3-pyridinyl)-6-(4-morpholinyl)imidazo[1,2-a]pyridine;
N′-(2-chloro-5-(6-(4-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-N,N-dimethylsulfamide;
N′-(2-chloro-5-(6-(2-(trifluoromethyl)-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-N,N-dimethylsulfamide;
N-(2-chloro-5-(7-(3-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)methanesulfonamide;
N′-(2-chloro-5-(7-(4-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-N,N-dimethylsulfamide;
N′-(2-chloro-5-(7-(3-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-N,N-dimethylsulfamide; or
N′-(2-chloro-5-(7-methyl-6-(4-pyridinyl)imidazo[1,2-a]pyridin-3-yl)-3-pyridinyl)-N,N-dimethylsulfamide.
2. A pharmaceutical composition comprising: a compound in accordance with claim 1 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable excipient.