Methods for preventing and treating angioedema
View Patent ↗One aspect of the present invention provides a method of treating or preventing angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R. One aspect of the present invention provides a method of treating or preventing vascular permeability in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R.
1. A method of treating angioedema in a patient in need thereof comprising administering to the patient a therapeutically effective amount of an agent that is capable of inhibiting the interaction of HK with gC1q-R, wherein the agent binds to the HK binding site of gC1q-R or wherein the agent binds to a gC1q-R binding site of HK.
2. The method of claim 1 , wherein the agent comprises an antibody or polypeptide.
3. The method of claim 2 , wherein the agent is an antibody that binds to a HK-binding site of gC1q-R.
4. The method of claim 2 , wherein the antibody binds to a gC1q-R binding site of HK.
5. The method of claim 2 , wherein the agent is a polypeptide selected from the group consisting of SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, and SEQ ID NO:16.
6. The method of claim 1 , wherein the patient is taking an ACE inhibitor.