Compounds, pharmaceutical compositions and methods of use of 2-aryl pyridylazoles
A 2-aryl-pyridylazole compound and derivatives useful in slowing the growth of cancer cells are disclosed. Also disclosed are methods of synthesizing the compound, methods of using pharmaceutical compositions containing the compound as an ingredient to slow the growth of cancer cells, and methods of treating cancer patients with pharmaceutical compositions containing the compound as an ingredient.
1. A compound with the formula;
wherein R 5 is selected from the group consisting of H, alkyl, OH, OR′, SH, S(O) n R′, halogen, CN, CO 2 H, CO 2 R′, CONHR′, SO 2 NHR′, CF 3 , OCF 3 , and O(CH 2 ) n O wherein R′ is selected from the group consisting of H and lower alkyl and wherein n is an integer;
wherein R 6 is selected from the group consisting of H, alkyl, OH, OR′, SH, S(O) n R′, halogen, CN, CO 2 H, CO 2 R′, CONHR′, SO 2 NHR′, CF 3 , OCF 3 , and O(CH 2 ) n O wherein R′ is selected from the group consisting of H and lower alkyl and wherein n is an integer;
wherein R 1 is selected from the group consisting of H, alkyl, OH, OR′, SH, S(O) n R′, halogen, ON, CO 2 H, CO 2 R′, CONHR′, SO 2 NHR′, CF 3 , OCF 3 , and O(CH 2 ) n O wherein R′ is selected from the group consisting of H and lower alkyl and wherein n is an integer;
wherein R 2 is selected from the group consisting of H, alkyl, OH, OR′, SH, S(O) n R′, halogen, CN, CO 2 H, CO 2 R′, CONHR′, SO 2 NHR′, CF 3 , OCF 3 , and O(CH 2 ) n O wherein R′ is selected from the group consisting of H and lower alkyl and wherein n is an integer; and
wherein R 3 is selected from the group consisting of H, alkyl, OH, OR′, SH, S(O) n R′, halogen, ON, CO 2 H, CO 2 R′, CONHR′, SO 2 NHR′, CF 3 , OCF 3 , and O(CH 2 ) n O wherein R′ is selected from the group consisting of H and lower alkyl and wherein n is an integer.
2. The compound of claim 1 further comprising a pharmaceutically acceptable salt thereof.
3. A method of slowing the expansion of a pancreatic cancer cell comprising:
administering an effective amount of a pharmaceutical composition comprising the compound of claim 1 or pharmaceutically acceptable salts thereof to the pancreatic cancer cell.
4. The method of claim 3 wherein the pharmaceutical composition further comprises a pharmaceutically acceptable carrier.
5. The method of claim 3 wherein the compound is
6. A method of treating cancer comprising:
administering to a mammal having cancer an effective amount of a first pharmaceutical composition comprising an effective amount of a pharmaceutical composition comprising the compound of claim 1 or pharmaceutically acceptable salts thereof.
7. The method of claim 6 wherein the first pharmaceutical composition further comprises a pharmaceutically acceptable carrier.
8. The method of claim 6 wherein the mammal is a human.
9. The method of claim 6 wherein the compound is
10. The method of claim 6 wherein the cancer is selected from the group consisting of: pancreatic cancer, ovarian cancer, breast cancer, colon cancer, myeloma, leukemia, kidney cancer, and lung cancer.
11. The method of claim 6 wherein the cancer is metastatic.