Antimicrobial compositions and methods of use thereof
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
1. A method of treating Escherichia coli infection, comprising:
administering to a subject in need thereof an effective amount of an antibacterial peptide comprising the amino acid sequence of SEQ ID NO: 3.
2. The method of claim 1 , wherein said antimicrobial peptide further comprises a cell penetrating peptide (CPP) domain.
3. The method of claim 1 , wherein said antimicrobial peptide further comprises a targeting domain.
4. The method of claim 1 , wherein said antimicrobial peptide is administered in combination with another antimicrobial agent.
5. The method of claim 4 , wherein said another antimicrobial agent is another antimicrobial peptide.
6. The method of claim 4 , wherein said another antimicrobial agent is an in vivo expression vector encoding said antimicrobial peptide.
7. The method of claim 4 , wherein said antimicrobial peptide is a PEGylated peptide.
8. A method of treating Escherichia coli infection, comprising:
administering to a subject in need thereof an effective amount of an in vivo polynucleotide expression vector that encodes an antibacterial peptide comprising the amino acid sequence of SEQ ID NO: 3,
wherein said in vivo expression vector expresses said antibacterial peptide in said subject.
9. A method of treating Escherichia coli infection, comprising:
administering to a subject in need thereof an effective amount of a bacteria phage displaying an antibacterial peptide on its surface,
wherein said antibacterial peptide comprises the amino acid sequence of SEQ ID NO: 3.