IP Library › Granted Patent US 8,367,613
Granted Patent B2
US 8,367,613 · App. 13/271,795 · Granted Feb 5, 2013

Resuscitation fluid

Inventor: Cuthbert O. Simpkins (Shreveport, LA)
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Quick Facts
Patent No.
US 8,367,613
App. No.
13/271,795
Granted
Feb 5, 2013
Kind
B2
Abstract

A method for treating conditions related to lack of blood supply with a lipid based resuscitation fluid is disclosed. The resuscitation fluid contains a lipid component and an aqueous carrier. The lipid component forms an emulsion with the aqueous carrier. The resuscitation fluid can be used to increase the blood pressure and to carry oxygen to tissues. The resuscitation fluid can also be used for preserving the biological integrity of donor organs for transplantation.

Claims (15)

1. A lipid based resuscitation fluid, comprising:

an oxygenated lipid emulsion; and

a buffering agent

wherein said lipid emulsion comprises a lipid component and an aqueous carrier, wherein said lipid component forms the emulsion with said aqueous carrier in the form of lipid micelles with a polar outer surface and an inner hydrophobic space.

2. The resuscitation fluid of claim 1 , further comprising a plasma component.

3. The resuscitation fluid of claim 1 , wherein said lipid emulsion comprises 20% (w/v) purified soybean oil, 1.2% (w/v) purified egg phospholipids, and 22% (w/v) glycerol anhydrous, and wherein said plasma component is approximately 5% (w/v) albumin.

4. The resuscitation fluid of claim 1 , wherein the buffering agent comprises histidine.

5. The resuscitation fluid of claim 1 , further comprising at least one additive selected from the group consisting of oncotic agents, crystalloid agents, buffering agents, carbohydrates, salts, vitamins, antibodies, and surfactants.

6. The resuscitation fluid of claim 1 , further comprising histidine at a concentration of between 0.01M to 0.2M.

7. The resuscitation fluid of claim 1 , further comprising hydrogen sulfide or carbon monoxide.

8. The resuscitation fluid of claim 1 , wherein the total oxygen contained in the lipid emulsion is greater than that present in the same liquid at atmospheric equilibrium conditions.

9. A method for preserving the biological integrity of an organ of a mammalian donor organism, comprising:

perfusing said organ with an effective amount of the lipid based resuscitation fluid of claim 1 .

10. The method of claim 9 , further comprising:

oxygenating the lipid based resuscitation fluid prior to perfusion.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 7, 2015
From: SIMPKINS, CUTHBERT O.
To: VIVACELLE BIO, INC.
Reel/Frame 035588/0864 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 22, 2014
From: SIMPKINS, CUTHBERT O.
To: VIVACELLE BIO, INC.
Reel/Frame 033791/0481 →
Continuity (4)
Continuation 12314737 · Dec 16, 2008
Provisional Application 61016443 · Dec 22, 2007
Provisional Application 61064639 · Mar 18, 2008
Related Publication 20120028235A1 · Feb 2, 2012