Compounds, compositions and methods useful for cholesterol mobilisation
The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
1. A compound of Formula (II):
or a pharmaceutically acceptable salts thereof, wherein
each R 9 is independently —H, -hydrocarbyl, -aryl, -aralkyl, -heteroaryl, -heterocyclyl, —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), N(alkyl)C(O)(alkyl), or —SO 2 NH 2 ;
each R 10 is independently —H, —OH, —NH 2 , —NH(alkyl), —N(alkyl)(alkyl), hydrocarbyl, —O-alkyl, —O-alkenyl, aryl, —O-aryl, aralkyl, —O-aralykl, heteroaryl, —O-heteroaryl, heterocyclyl, —O-heterocyclyl, halo, —OCF 3 , —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), NHC(O)(C 2 -C 10 -alkyl), N(alkyl)C(O)(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)N(alkyl)(alkyl), —CHNH, —CHN(alkyl), or —SO 2 NH 2 ;
each of Q 1 , Q 2 , and Q 3 is independently CR 10 or N;
X is CHR 10 , S, O, or NR 9 ; and
each m is independently an integer from 0-3.
2. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt of any of the foregoing.
3. A composition comprising an effective amount of a compound or pharmaceutically acceptable salt of the compound of claim 1 and a pharmaceutically acceptable vehicle or carrier.
4. The compound or pharmaceutically acceptable salt of the compound of claim 1 , wherein R 9 is H and R 10 is OH.
5. The compound or pharmaceutically acceptable salt of the compound of claim 4 , wherein each m is 1.
6. The composition of claim 3 , wherein the composition is formulated for oral administration.
7. The composition of claim 3 , wherein the composition is in the form of a tablet or capsule.
8. The composition of claim 3 , wherein the compound or pharmaceutically acceptable salt thereof is present in an amount of about 1 mg to about 1,000 mg.