IP Library Granted Patent US 8,846,183
Granted Patent B2
US 8,846,183 · App. 13/278,061 · Granted Sep 30, 2014

Microfabricated elastomeric valve and pump systems

Inventors: Marc A. Unger (San Mateo, CA); Hou-Pu Chou (Sunnyvale, CA); Todd A. Thorsen (Pasadena, CA); Axel Scherer (Laguna Beach, CA); Stephen R. Quake (Stanford, CA)
Assignee: California Institute of Technology
C12Q1/6874B01L2200/027B01L2300/0887B81C2201/019F16K2099/0094B81B2201/036B01J2219/00398B01L2200/10F16K2099/0078B01L3/50273B01J2219/00707B01L3/502707B01J2219/00725B01J2219/00659B32B2037/1081F16K99/0001B81C1/00119F16K99/0046B01L2300/0681B01J2219/00355B01L2300/123B81B2201/054F16K99/0015B01L2300/18B01L3/502738B01L2300/0861F16K2099/0076B01J2219/00378F16K2099/008B01L2400/0655B01J2219/00527B01J2219/00396F16K99/0059B01L2200/0605F04B43/043B01L2200/025B01J2219/005B01L2400/0688F15C5/00B01L2400/046B01L2400/0481B01L9/527B01J2219/00439B01J2219/00722B01L7/54B01J2219/00612B01L2300/14F16K2099/0074F16K99/0051B01J2219/00605
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Quick Facts
Patent No.
US 8,846,183
App. No.
13/278,061
Granted
Sep 30, 2014
Kind
B2
Abstract

A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

Claims (25)

1. A composite structure comprising:

an elastomer component with a Young's Modulus between about 50 Pa and about 10 MPa including a micro-recess;

a substantially planar nonelastomer component sealed against the elastomer component; and

an active device disposed within the nonelastomer component, wherein the active device is an electronic device configured to interact with a material present in the micro-recess.

2. The composite structure of claim 1 wherein the electronic device is selected from the group consisting of a photodiode, a fiber optic device, a fiber optic interconnect, a light emitting diode, a laser diode, vertical cavity surface emitting laser (VCSEL), a micromirror, a CMOS imaging array, a CCD camera, a waveguide, and a source or a receiver for visible, infrared, or ultraviolet regions of the electromagnetic spectrum.

3. The composite structure of claim 1 wherein the electronic device is selected from the group consisting of a resistor, a capacitor, a transistor, a chemical field effect transistor, a amperometric/coulometric electrochemical sensor, an accelerometer, a pressure sensor, a flow sensor, an electronic logic structure, a microprocessor, a chemical sensor, a strain gauge, an inductor, an actuator, a coil, a magnet, an electromagnet, a magnetic sensor, a radio frequency source, a radio frequency receiver, a microwave frequency source, a microwave frequency receiver, a radioactive particle counter, and an electrometer.

4. The composite structure of claim 1 wherein the electronic device is selected from the group consisting of a thermistor, a Peltier cooler, and a resistive heater.

5. The composite structure of claim 1 wherein elastomer component comprises a membrane portion and wherein the electronic device is an electrode that electrostatically drives the membrane portion of the elastomer component into the micro-recess.

6. The composite structure of claim 1 wherein the electronic device comprises an electrochemical sensor.

7. A method of fabricating a composite structure comprising:

forming a micro-recess in an elastomer component, wherein the elastomer component has a Young's Modulus between about 50 Pa and about 10 MPa;

forming a substantially planar nonelastomer component with an active device, disposed within the nonelastomer component; and

sealing the elastomer component against the nonelastomer component, such that the active device is an electronic device configured to interact with a material present within the micro-recess.

8. The method of claim 6 wherein sealing the elastomer component against the nonelastomer component comprises forming a Van der Waals chemical bond.

9. The method of claim 6 wherein sealing the elastomer component against the nonelastomer component comprises:

placing the elastomer component against the non-elastomeric component with a liquid layer, and

removing the liquid layer.

10. The method of claim 6 wherein sealing the elastomer component against the nonelastomer component comprises forming a covalent chemical bond.

11. The method of claim 6 wherein sealing the elastomer component against the nonelastomer component comprises forming an ionic chemical bond.

12. The method of claim 6 wherein the electronic device comprises a device selected from the group consisting of a photodiode, a fiber optic device, a fiber optic interconnect, a light emitting diode, a laser diode, vertical cavity surface emitting laser (VCSEL), a micromirror, a CMOS imaging array, a CCD camera, a waveguide, and a source or a receiver for visible, infrared, or ultraviolet regions of the electromagnetic spectrum.

13. The method of claim 6 wherein the electronic device comprises an electronic structure selected from the group consisting of a resistor, a capacitor, a transistor, a chemical field effect transistor, a amperometric/coulometric electrochemical sensor, an accelerometer, a pressure sensor, a flow sensor, an electronic logic structure, a microprocessor, a chemical sensor, a strain gauge, an inductor, an actuator, a coil, a magnet, an electromagnet, a magnetic sensor, a radio frequency source, a radio frequency receiver, a microwave frequency source, a microwave frequency receiver, a radioactive particle counter, and an electrometer.

14. The method of claim 6 wherein the electronic device comprises a thermal structure selected from the group consisting of a thermistor, a Peltier cooler, and a resistive heater.

15. The method of claim 6 wherein the electronic device is formed in the nonelastomer component by a technique selected from the group consisting of PCB technology, CMOS, surface micromachining, bulk micromachining, printable polymer electronics, Thin Film Transistor, and other amorphous/polycrystalline material techniques.

16. The method of claim 6 wherein the electronic device formed in the nonelastomer component comprises an electrochemical sensor.

17. The composite structure of claim 1 wherein the elastomer component comprises a ceiling and walls for forming the micro-recess, and wherein the nonelastomer component comprises a floor located opposite the ceiling, and wherein the electronic device is located within the floor, and wherein the ceiling is a membrane that can be moved against the floor.

Assignments (2)
CONFIRMATORY LICENSE Recorded Apr 10, 2012
From: CALIFORNIA INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028018/0980 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 1, 2012
From: UNGER, MARC A.; CHOU, HOU-PU; THORSEN, TODD A.; SCHERER, AXEL; QUAKE, STEPHEN R.
To: CALIFORNIA INSTITUTE OF TECHNOLOGY
Reel/Frame 027792/0507 →
Continuity (8)
Division 12556373 · Sep 9, 2009
Continuation 11552644 · Oct 25, 2006
Division 09724784 · Nov 28, 2000
Continuation In Part 09605520 · Jun 27, 2000
Provisional Application 60186856 · Mar 3, 2000
Provisional Application 60147199 · Aug 3, 1999
Provisional Application 60141503 · Jun 28, 1999
Related Publication 20120091374A1 · Apr 19, 2012