Maribavir isomers, compositions, methods of making and methods of using
The invention relates to novel compositions and methods of using maribavir which enhance its effectiveness in medical therapy, as well as to maribavir isomers and methods of use thereof for counteracting the potentially adverse effects of maribavir isomerization in vivo in the event it occurs.
1. A method of increasing the bioavailability of maribavir to a patient receiving maribavir therapy comprising administering to said patient an oral dose comprising about 200 mg to 800 mg of maribavir under fasted conditions, whereby said administration results in an increase of (1) the maximum plasma concentration, (2) the extent of absorption of maribavir relative to the plasma concentration, and (3) the extent of absorption for the corresponding administration of maribavir under fed conditions.