Crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole
The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy.
1. Crystalline Form VII of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole having an X-ray powder diffraction pattern selected from the group consisting of those substantially as shown in FIG. 1A .
2. A crystalline form of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole having an X-ray powder diffraction pattern selected from the group consisting of those substantially as shown in FIGS. 2A-8A .
3. A pharmaceutical composition comprising a crystalline form of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole according to claim 1 and at least one pharmaceutically acceptable carrier.
4. A pharmaceutical composition according to claim 3 in the form of a powder, tablet, capsule or suspension.
5. A composition comprising an admixture of crystalline Form VII of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole, together with at least one of Form I, Form II, ethanol solvate, Form IV, Form V, Form VI and amorphous 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole.
6. A composition comprising an admixture of a crystalline form of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole according to claim 2 , together with at least one of Form I, Form II, ethanol solvate, Form IV, Form V, Form VI and amorphous 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole.
7. A method for treatment or prophylaxis of a herpes viral infection in a patient in need thereof comprising administering to said patient an effective anti-viral amount of crystalline Form VII of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole.
8. A method according to claim 7 , wherein said herpes viral infection is cytomegalovirus (CMV).
9. A method for treatment or prophylaxis of a herpes viral infection in a patient in need thereof comprising administering to said patient an effective anti-viral amount of a crystalline form of 5,6-dichloro-2-(isopropylamino)-1-β-L-ribofuranosyl)-1H-benzimidazole, according to claim 2 .
10. A method according to claim 7 , wherein said herpes viral infection is cytomegalovirus (CMV).