Cryogenic balloon device with radiofrequency tip
An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.
1. A medical device, comprising:
an elongate catheter body including a proximal portion coupled to a handle and a distal portion;
a cryogenic treatment region coupled to the distal portion of the catheter body; and
at least one of a radiofrequency treatment region and an electroporation treatment region coupled to the distal portion of the catheter body at a location that is distal to the cryogenic treatment region and defining an outer surface of and a distal tip of the medical device.
2. The medical device of claim 1 , wherein the cryogenic treatment region includes an expandable element.
3. The medical device of claim 2 , wherein the at least one of a radiofrequency treatment region and an electroporation treatment region includes a substantially linear thermal segment.
4. The medical device of claim 1 , wherein the cryogenic treatment region is operable independently from the at least one of a radio frequency treatment region and an electroporation treatment region.
5. The medical device of claim 1 , further comprising a fluid flow path in fluid communication with the cryogenic treatment region.
6. The medical device of claim 5 , further comprising a cryogenic fluid source in fluid communication with the first fluid flow path.
7. The medical device of claim 6 , further comprising a radiofrequency signal source coupled to the at least one of a radiofrequency treatment region and an electroporation treatment region.
8. The medical device of claim 1 , further comprising a sensor coupled to at least one of the cryogenic treatment region or the at least one of a radiofrequency treatment region and an electroporation treatment region.
9. The medical device of claim 1 , wherein the at least one of a radiofrequency treatment region and an electroporation treatment region is deflectable independently of the cryogenic treatment region.
10. An intravascular ablation device, comprising:
a flexible elongate body including a proximal portion coupled to a handle and a distal portion;
an expandable element coupled to the distal portion of the elongate body;
a substantially linear, elongated radiofrequency thermal segment coupled to the distal portion of the elongate body and extending distally beyond the expandable element when the expandable element is fully expanded;
a cryogenic coolant source in fluid communication with an interior of the expandable element; and
a radiofrequency energy source in communication with the radiofrequency thermal segment.
11. The intravascular ablation device of claim 10 , wherein radiofrequency thermal segment includes an electrically-conductive distal tip.
12. A method of treating cardiac tissue, comprising:
positioning an expandable cryogenic treatment region proximate a pulmonary vein, the cryogenic treatment region being coupled to a distal portion of a medical device;
ablating tissue proximate the pulmonary vein with the expandable cryogenic treatment region;
positioning a radiofrequency treatment region proximate the pulmonary vein, the radiofrequency treatment region including an electrode coupled to distal portion of the medical device at a location distal to the cryogenic treatment region when the cryogenic treatment region is fully expanded; and
ablating tissue proximate the pulmonary vein with the radiofrequency treatment region.
13. The method of claim 12 , wherein positioning the expandable cryogenic treatment region includes expanding the expandable cryogenic treatment region in the pulmonary vein to substantially occlude the pulmonary vein.
14. The method of claim 13 , wherein ablating tissue proximate the pulmonary vein with the expandable cryogenic treatment region includes circulating a cryogenic fluid through the expandable cryogenic treatment region.
15. The method of claim 13 , wherein ablating tissue proximate the pulmonary vein with the expandable cryogenic treatment region includes creating a first ablative treatment pattern, and wherein ablating tissue proximate the pulmonary vein with the radiofrequency treatment region includes creating a second ablative treatment pattern.
16. The method of claim 15 , wherein the first ablative treatment pattern includes a substantially arcuate shape.
17. The method of claim 16 , wherein the second ablative treatment pattern includes a substantially focal shape.
18. The method of claim 17 , wherein the first and second ablative treatment patterns are substantially continuous.
19. The medical device of claim 9 , wherein the medical device further comprises a deflectable segment located between the at least one of a radiofrequency treatment region and an electroporation treatment region and the expandable cryogenic treatment region, the deflectable segment facilitating deflection of the at least one of a radiofrequency treatment region and an electroporation treatment region relative to the expandable cryogenic treatment region.