ANALYTE SENSING BIOINTERFACE
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
1 . A glucose sensor configured for implantation in a host, comprising:
a biocompatible matrix comprising a scaffolding having a porosity;
a working electrode comprising an electrically conductive material, wherein an electroactive surface of the working electrode is distributed throughout the biocompatible matrix; and
electronics electrically coupled to the working electrode, wherein, in use, the electronics are configured to detect a current flowing through the working electrode or a voltage of the working electrode, wherein the current or voltage is indicative of a quantity of an analyte within the porosity.
2 . The glucose sensor of claim 1 , wherein the scaffolding comprises an electrically non-conductive material.
3 . The glucose sensor of claim 2 , wherein the scaffolding further comprises an electrically conductive material.
4 . The glucose sensor of claim 1 , wherein the scaffolding is substantially planar.
5 . The glucose sensor of claim 1 , wherein the biocompatible matrix comprises an enzyme.
6 . The glucose sensor of claim 5 , wherein the biocompatible matrix further comprises a resistance domain disposed over the enzyme.
7 . The glucose sensor of claim 5 , wherein the biocompatible matrix further comprises a bioactive agent.
8 . A sensor for measuring glucose in a host, the sensor comprising:
a biointerface, the biointerface comprising a porous biointerface material, wherein electroactive surfaces are distributed within at least some pores in the biointerface, and wherein the electroactive surfaces have a membrane coating disposed thereon; and
electronics electrically coupled to the sensor, such that, in use, the electronics are configured to detect a current or a voltage indicative of a quantity of glucose within the pores.
9 . The sensor of claim 8 , wherein the biointerface comprises an electrically non-conductive material.
10 . The sensor of claim 9 , wherein the biointerface further comprises an electrically conductive material.
11 . The sensor of claim 8 , wherein the biointerface is substantially planar.
12 . The sensor of claim 8 , wherein the biointerface comprises an enzyme.
13 . The sensor of claim 12 , wherein the biointerface further comprises a resistance domain disposed over the enzyme.
14 . The sensor of claim 8 , wherein the biointerface further comprises a bioactive agent.