Piperidinone carboxamide azaindane CGRP receptor antagonists
View Patent ↗The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
1. The compound
or a pharmaceutically acceptable salt thereof.
2. The compound
or a pharmaceutically acceptable salt thereof.
3. The compound
or a pharmaceutically acceptable salt thereof.
4. The compound
or a pharmaceutically acceptable salt thereof.
5. A compound selected from the following group:
R 1
3,3,3-trifluoropropyl
2-methylpropyl
(2S)-3,3,3-trifluoro-2-hydroxypropyl
cyclopropylmethyl
[1-(trifluoromethyl)cyclopropyl]methyl
2,2-difluoroethyl
[(1R)-2,2-difluorocyclopropyl]methyl
[(1S)-2,2-difluorocyclopropyl]methyl
or a pharmaceutically acceptable salt of any of the foregoing compounds.
6. The compound
7. A pharmaceutical composition which comprises an inert carrier and the compound of claim 1 , or a pharmaceutically acceptable salt thereof.
8. A pharmaceutical composition which comprises an inert carrier and the compound of claim 2 , or a pharmaceutically acceptable salt thereof.
9. A pharmaceutical composition which comprises an inert carrier and the compound of claim 3 , or a pharmaceutically acceptable salt thereof.
10. A pharmaceutical composition which comprises an inert carrier and the compound of claim 4 , or a pharmaceutically acceptable salt thereof.
11. A pharmaceutical composition which comprises an inert carrier and a compound of claim 5 , or a pharmaceutically acceptable salt thereof.