Methods and compositions for prevention and treatment of inflammatory disease, autoimmune disease and transplant rejection
View Patent ↗The invention provides compositions and methods for reducing one or more symptoms of an autoimmune disease, inflammatory disease, and/or transplant rejection, by the administration to a subject in need thereof a pharmaceutically effective amount of a purified compound of any one of Formulae A-E. The invention's methods are useful for the prevention, amelioration, and treatment of autoimmune disease, inflammatory disease, and/or transplant rejection.
1. A method for reducing one or more symptoms of multiple sclerosis in a subject, wherein said method comprises administering to said subject a pharmaceutically effective amount of purified piceatannol (3,3′,4,5′-tetrahydroxy trans stilbene), wherein said subject is selected from the group consisting of human, mouse and canine.
2. The method of claim 1 , wherein said administering is selected from the group consisting of parenteral, oral, and intraperitoneal.
3. The method of claim 1 , wherein said administering is before manifestation of one or more symptoms of multiple sclerosis.
4. The method of claim 1 , wherein said administering is concomitant with manifestation of one or more symptoms of multiple sclerosis.
5. The method of claim 1 , wherein said administering is after manifestation of one or more symptoms of multiple sclerosis.
6. The method of claim 1 , wherein said one or more symptoms comprise paralysis.