Family of PFKFB3 inhibitors with anti-neoplastic activities
A methods and compounds for inhibiting 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) are described. Also described are methods of inhibiting cell proliferation, treating cancer, and screening compounds to determine their ability to inhibit PFKFB3.
1. A compound or an optical isomer or stereoisomer or racemic mixture thereof, the compound having the Formula:
wherein Ar 1 is substituted or unsubstituted and is selected from the group consisting of phenyl, 2-pyridyl, 3-pyridyl, 4-pyridyl, 3,5-pyrimidinyl, and 2,4-pyrimidinyl, wherein Ar 1 substitutions are selected from the group consisting of H, F, Cl, OH, alkyl, O-alkyl, amino, alkylamino, carboxyl, aminocarbonyl, alkylaminocarbonyl, and combinations thereof;
Y 6 , Y 11 and Y 12 , are independently selected from the group consisting of N and CR, wherein when one of Y 6 , Y 11 , or Y 12 is N, the other two are CR;
Y 17 , Y 18 , and Y 19 are independently selected from the group consisting of N and CR, wherein when one of Y 17 , Y 18 , or Y 19 is N, the other two are CR;
each of Y 7 , Y 8 , Y 9 , Y 10 , Y 13 , Y 14 , Y 15 , and Y 16 is CR; and
each R is independently selected from the group consisting of H, F, OH, alkyl, amino, alkylamino, carboxyl, aminocarbonyl, alkylaminocarbonyl, and combinations thereof.
2. A compound selected from the group consisting of:
1-Naphthalen-2-yl-3-quinolin-2-yl-propenone;
1-Naphthalen-2-yl-3-quinolin-3-yl-propenone;
3-(4-Hydroxy-quinolin-2-yl)-1-pyridin-4-yl-propenone;
3-(8-Hydroxy-quinolin-2-yl)-1-pyridin-3-yl-propenone;
3-Quinolin-2-yl-1-p-tolyl-propenone;
3-(8-Hydroxy-quinolin-2-yl)-1-pyridin-4-yl-propenone;
3-(8-Hydroxy-quinolin-2-yl)-1-p-tolyl-propenone;
3-(4-Hydroxy-quinolin-2-yl)-1-p-tolyl-propenone;
1-Phenyl-3-quinolin-2-yl-propenone;
1-(2-Hydroxy-phenyl)-3-quinolin-2-yl-propenone;
1-(4-Hydroxy-phenyl)-3-quinolin-2-yl-propenone;
1-(2-Amino-phenyl)-3-quinolin-2-yl-propenone;
1-(4-Amino-phenyl)-3-quinolin-2-yl-propenone;
4-(3-Quinolin-2-yl-acryloyl)-benzamide;
4-(3-Quinolin-2-yl-acryloyl)-benzoic acid;
3-(8-Methyl-quinolin-2-yl)-1-pyridin-4-yl-propenone;
1-(2-Fluoro-pyridin-4-yl)-3-quinolin-2-yl-propenone;
3-(8-Fluoro-quinolin-2-yl)-1-pyridin-4-yl-propenone;
3-(6-Hydroxy-quinolin-2-yl)-1-pyridin-4-yl-propenone;
3-(8-Methylamino-quinolin-2-yl)-1-pyridin-4-yl-propenone;
3-(7-Methyl-quinolin-2-yl)-1-pyridin-4-yl-propenone; and
1-Methyl-4-[3-(8-methyl-quinolin-2-yl)-acryloyl]-pyridinium.
3. The compound