Fused heterocyclic derivatives and methods of use
Selected compounds are effective for prophylaxis and treatment of diseases, such as HGF mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
1. A compound selected from
or a pharmaceutically acceptable salt thereof.
2. A compound or a pharmaceutically acceptable salt thereof, selected from
3. A compound or a pharmaceutically acceptable salt thereof, selected from
4. A compound or a pharmaceutically acceptable salt thereof, selected from
5. A pharmaceutical composition comprising a compound of any of claim 1 , 2 , 3 or 4 together with a pharmaceutically acceptable vehicle or carrier.
6. A compound or a pharmaceutically acceptable salt thereof, selected from
7. A pharmaceutical composition comprising a compound of claim 6 together with a pharmaceutically acceptable vehicle or carrier.
8. A method of treating gastric cancer or glioblastoma in a subject, said method comprising administering an effective amount of a compound as in any of the preceding claims.