IP Library Granted Patent US 10,456,369
Granted Patent B2
US 10,456,369 · App. 13/318,236 · Granted Oct 29, 2019

Methods and compositions for improving the health of animals

Inventors: Janusz Daroszewski (Ottawa, CA); Clayton Paul Dick (Guelph, CA); Isabella Verzberger-Epshtein (Stratford, CA)
Assignee: Avivagen Inc.
A61K31/12A23K20/179A23K50/40A61K9/0056A61K31/336
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Quick Facts
Patent No.
US 10,456,369
App. No.
13/318,236
Granted
Oct 29, 2019
Kind
B2
Abstract

The invention features compositions and methods for the administration of an oxidatively transformed carotenoid, or a component thereof, for improving the health of animals, such as increasing joint mobility, increasing activity, and improving coat quality. In particular, methods for improving the health of animals comprise administering compositions comprising an oligomeric material formed by reaction of oxygen with a carotenoid.

Claims (30)

1. A method of reducing shedding in a canine animal in need thereof, said method comprising administering to said canine animal a composition comprising an oligomeric material in an amount sufficient to reduce shedding, wherein said oligomeric material is formed by reaction of 6 to 8 molar equivalents of oxygen with a carotenoid and has a median molecular weight of about 900 Daltons, and wherein from 0.1 mg/kg body weight to 3 mg/kg body weight of said oligomeric material is administered to said canine animal daily.

2. The method of claim 1 , wherein said composition is mixed with food and administered orally to said canine animal.

3. The method of claim 2 , wherein said food is a wet animal food or a dry animal food or said food is in the form of a kibble, a chew, a tablet, or a soft edible treat.

4. The method of claim 1 , wherein said composition is administered to said canine animal as an oral supplement.

5. The method of claim 4 , wherein said oral supplement is a palatable paste or gel.

6. The method of claim 5 , wherein said paste or gel comprises from 2 mg/tablespoon to 750 mg/tablespoon of said oligomeric.

7. The method of claim 1 , wherein said canine animal is a mature canine animal.

8. The method of claim 1 , wherein said composition is provided in a comestible solid composition in a unit dosage form comprising from 2 mg to 130 mg of said oligomeric material and is formulated to be palatable to canines.

9. The method of claim 8 , wherein said comestible solid composition in a unit dosage form is a kibble, a chew, a tablet, or a soft edible treat.

10. The method of claim 8 , wherein said comestible solid composition in a unit dosage form is a chewable tablet and wherein said unit dosage form comprises from 2 mg to 75 mg of said oligomeric material.

11. A method of increasing joint mobility of a canine animal having poor joint mobility or increasing the activity level in a canine animal having a low activity level, said method comprising administering to said canine animal a composition comprising an oligomeric material in an amount sufficient to increase said joint mobility or increase said activity level, wherein said oligomeric material is formed by reaction of 6 to 8 molar equivalents of oxygen with a carotenoid and has a median molecular weight of about 900 Daltons, and wherein from 0.1 mg/kg body weight to 3 mg/kg body weight of said oligomeric material is administered to said canine animal daily.

12. The method of claim 11 , wherein said composition is mixed with food and administered orally to said canine animal.

13. The method of claim 12 , wherein said food is a wet animal food or a dry animal food or said food is in the form of a kibble, a chew, a tablet, or a soft edible treat.

14. The method of claim 11 , wherein said composition is administered to said canine animal as an oral supplement.

15. The method of claim 14 , wherein said oral supplement is a palatable paste or gel.

16. The method of claim 15 , wherein said paste or gel comprises from 2 mg/tablespoon to 750 mg/tablespoon of said oligomeric material.

17. The method of claim 11 , wherein said canine animal is a mature canine animal.

18. The method of claim 11 , wherein said composition comprising is provided in a comestible solid composition in a unit dosage form comprising from 2 mg to 130 mg of said oligomeric material and is formulated to be palatable to canines.

19. The method of claim 18 , wherein said comestible solid composition in a unit dosage form is a kibble, a chew, a tablet, or a soft edible treat.

20. The method of claim 18 , wherein said comestible solid composition in a unit dosage form is a chewable tablet and wherein said unit dosage form comprises from 2 mg to 75 mg of said oligomeric material.

21. A method of reducing discoloration in an eye of a canine animal having pigmentation spots in said eye, said method comprising administering to said canine animal a composition comprising an oligomeric material in an amount sufficient to reduce said discoloration, wherein said oligomeric material is formed by reaction of 6 to 8 molar equivalents of oxygen with a carotenoid and has a median molecular weight of about 900 Daltons, and wherein said discoloration is discoloration arising from said pigmentation spots, and wherein from 0.1 mg/kg body weight to 3 mg/kg body weight of said oligomeric material is administered to said canine animal daily.

22. The method of claim 21 , wherein said composition is mixed with food and administered orally to said canine animal.

23. The method of claim 22 , wherein said food is a wet animal food or a dry animal food or said food is in the form of a kibble, a chew, a tablet, or a soft edible treat.

24. The method of claim 21 , wherein said composition is administered to said canine animal as an oral supplement.

25. The method of claim 24 , wherein said oral supplement is a palatable paste or gel.

26. The method of claim 25 , wherein said paste or gel comprises from 2 mg/tablespoon to 750 mg/tablespoon of said oligomeric material.

27. The method of claim 21 , wherein said canine animal is a mature canine animal.

28. The method of claim 21 , wherein said composition is provided in a comestible solid composition in a unit dosage form comprising from 2 mg to 130 mg of said oligomeric material and is formulated to be palatable to canines.

29. The method of claim 28 , wherein said comestible solid composition in a unit dosage form is a kibble, a chew, a tablet, or a soft edible treat.

30. The method of claim 28 , wherein said comestible solid composition in a unit dosage form is a chewable tablet and wherein said unit dosage form comprises from 2 mg to 75 mg of said oligomeric material.

Assignments (3)
CHANGE OF NAME Recorded Dec 18, 2015
From: CHEMAPHOR INC.
To: AVIVAGEN INC.
Reel/Frame 037336/0473 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 26, 2013
From: DICK, CLAYTON PAUL
To: CHEMAPHOR INC.
Reel/Frame 031679/0695 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 4, 2012
From: DAROSZEWSKI, JANUSZ; VERZBERGER-EPSHTEIN, ISABELLA
To: CHEMAPHOR INC.
Reel/Frame 027476/0846 →
Continuity (2)
Provisional Application 61174259 · Apr 30, 2009
Related Publication 20130131183A1 · May 23, 2013