Recognizable carrier for optical measurement methods
The invention relates to a recognizable carrier for determining physical, chemical or biochemical interactions by means of optical measurement methods. The carrier comprises a surface that defines a substrate surface and that has a base layer coated with reactive elements, which are bonded to receptor molecules, wherein the base layer and/or the reactive elements are provided with a pattern of holes which forms a code and/or the reactive elements are provided with linker molecules or markers which form a code. The substrate surface may additionally have a macroscopically planar pattern which is applied using laser light or chemical etching and forms a code. The invention likewise relates to a method for producing a recognizable carrier for spectroscopic processes and/or intensiometric tests to determine said interactions. The code to recognize the carrier can be controlled via a read-out unit coupled to the photometric analysis unit. Such a carrier can be used to analyze biomolecules during security checks, access controls or in-vitro diagnostics.
1. A recognizable carrier for the determination of physical, chemical or biochemical interactions using optical measurement methods, comprising:
a plate surface,
a well formed in the plate surface, the well having a sidewall and a bottom surface which is at least partially chemically activated and defines a substrate surface,
a base layer disposed on the substrate surface and coated with reactive elements that binds to receptor molecules, and
an implicit coding for controlling authenticity and quality of the carrier, wherein the implicit coding is formed by a void pattern and a plurality of spots formed on at least one of the base layer and the reactive elements, wherein
the void pattern is formed by a plurality of voids or holes representing the implicit coding, and
the plurality of spots are disposed in a predetermined arrangement and have different heights representing the implicit coding.
2. The carrier of claim 1 , wherein the carrier is planar.
3. The carrier of claim 1 , wherein the substrate surface comprises an additional microscopic two-dimensional pattern applied with laser light or by chemical etching to form a coding forming pattern, and wherein the void pattern of the base layer and at least partially the pattern of the reactive elements correspond to the macroscopic two-dimensional pattern of the substrate surface.
4. The carrier of claim 1 , wherein the reactive elements comprise basic structures derived from alkenes with oligomer molecular components.
5. The carrier of claim 1 , wherein the carrier is made of glass in form of a flat carrier or a micro-titer plate.
6. The carrier of claim 1 , wherein the carrier is made of plastic in form of a flat carrier or a micro-titer plate.
7. The carrier of claim 5 , wherein the glass forming the micro-titer plate comprises borosilicate.
8. The carrier of claims 1 , wherein the plate surface of the carrier is reflecting or comprises elements selected from aluminum, zinc oxide, titanium oxide or mixtures thereof.
9. The carrier of claim 1 , wherein
the void pattern is formed on both the base layer and the reactive elements.
10. The carrier of claim 1 , wherein
the sidewall of the well has a predetermined height, and
the heights of the plurality of spots are lower than the predetermined height of the sidewall of the well.