Combination antineoplastic therapy
View Patent ↗The present invention is directed to methods of using a sirolimus drug and chloroquine or a quinoline derivative in combination. Methods of use are also described.
1. A method of limiting the growth and proliferation of a cancer that is renal cell carcinoma or glioblastoma in a patient having or suspected of having renal cell carcinoma or glioblastoma comprising:
co-administering to the patient a sirolimus drug together with chloroquine, the amounts of said sirolimus drug and chloroquine, in combination, being effective for achieving said limiting of growth and proliferation.
2. The method of claim 1 , wherein the limiting is achieved by modulating autophagy in the cancer cells.
3. The method of claim 1 wherein the sirolimus drug is sirolimus.
4. The method of claim 1 wherein the administration is concurrent.
5. The method of claim 1 wherein the administration is sequential.
6. The method of claim 1 wherein the sirolimus drug is temsirolimus.
7. A method of treating renal cell carcinoma or glioblastoma in a patient comprising administering to the patient a therapeutically effective amount of
a sirolimus drug; and
chloroquine.
8. The method of claim 7 comprising administration of sirolimus and chloroquine.
9. The method of claim 7 comprising administration of temsirolimus and chloroquine.
10. The method of claim 7 comprising administration of deforolimus, everolimus, temsirolimus, or zotarolimus and chloroquine.
11. The method of claim 7 wherein the administration is concurrent.
12. The method of claim 7 wherein the administration is sequential.