IP Library › Granted Patent US 9,421,211
Granted Patent B2
US 9,421,211 · App. 13/322,607 · Granted Aug 23, 2016

N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation

Inventors: Bertal Huseyin Aktas (Newton, MA); José A. Halperin (Brookline, MA); Michael Chorev (Chestnut Hill, MA)
Assignee: President and Fellows of Harvard College
A61K31/5377C07D213/75C07D249/14
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Quick Facts
Patent No.
US 9,421,211
App. No.
13/322,607
Granted
Aug 23, 2016
Kind
B2
Abstract

Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

Claims (2)

1. A method for inhibiting the proliferation of human cancer cells comprising contacting the cells selected from the group consisting of squamous carcinoma cells, human breast cancer cells, human melanoma cells, human lung cancer cells and human prostate cancer cells, with compound

2. The method of claim 1 wherein inhibiting the proliferation of human cancer cells comprises inhibiting translation initiation.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 10, 2012
From: AKTAS, HUSEYIN; CHOREV, MICHAEL; HALPERIN, JOSE A.
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 029107/0954 →
CONFIRMATORY LICENSE Recorded Jan 25, 2012
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 027589/0170 →
Continuity (2)
Provisional Application 61181920 · May 28, 2009
Related Publication 20120115915A1 · May 10, 2012