Needle array assembly and method for delivering therapeutic agents
A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
1. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein the device is configured to deliver the one or more agents at less than a minimal dose required to produce a detectable effect in an adult, undetectable outside the solid tissue, or a therapeutically effective amount.
2. The device of claim 1 , wherein each of the plurality of needles is configured to deliver the one or more agents in a column-shaped region coaxial with respect to the delivery axis.
3. The device of claim 1 , wherein the device is configured to deliver a first agent to a plurality of positions within the solid tissue.
4. The device of claim 1 , wherein the device is configured to deliver a plurality of different agents to a plurality of different positions within the solid tissue.
5. The device of claim 1 , wherein the needles are close-ended.
6. The device of claim 1 , wherein the device comprises needles with micro pits over their surfaces.
7. The device of claim 1 , further comprising a linkage to a data processing system.
8. The device of claim 7 , wherein the data processing system is in communicable connection with the needle array.
9. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein the device is configured for passive delivery of the one or more agents into the solid tissue.
10. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein an amount of agent in each of the plurality of needles is less than 1 μL per needle.
11. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein the device comprises more than one thousand needles.
12. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein the device comprises needles coated with nanowire.
13. A device for delivery of one or more agents into a solid tissue, comprising: a plurality of needles arranged in an array configured to deliver the one or more agents into the solid tissue along an axis of the plurality of needles; wherein the device comprises needles made from porous material.