Method of treating the surface of a medical device with a biomolecule
A method of treating the surface of a medical device with a biomolecule comprising the steps of: providing a polyolefin substrate forming a medical device; cleaning the polyolefin substrate; exposing the polyolefin substrate to a reactive gas containing acrylic acid and to plasma energy to yield a plasma-deposited polyacrylic acid coating on the polyolefin substrate; and attaching a biomolecule, such as heparin, to the polyolefin substrate following formation of the plasma-deposited polyacrylic acid coating on the polyolefin substrate.
1. A method of treating the surface of a medical device with a biomolecule comprising the steps of:
a) providing a polyolefin substrate forming a medical device;
b) cleaning the polyolefin substrate;
c) exposing the polyolefin substrate to at least one reactive gas containing plasma energy and at least one of acrylic acid and siloxane functional groups to yield at least one plasma-deposited coating on the polyolefin substrate;
d) rendering at least one plasma deposited coating amino functional following plasma deposition; and
e) attaching a biomolecule to the polyolefin substrate following formation of the at least one plasma-deposited coating on the polyolefin substrate, and wherein the biomolecule is at least one of an antibacterial agent, antimicrobial agent, anticoagulant, heparin, antithrombotic agent, platelet agent, anti-inflammatory, enzyme, catalyst, hormone, growth factor, drug, vitamin, antibody, antigen, nucleic acid, dye, a DNA segment, an RNA segment, protein, and peptide.
2. The method of treating the surface of a medical device with a biomolecule of claim 1 wherein the biomolecule is heparin.
3. The method of treating the surface of a medical device with a biomolecule of claim 2 wherein the polyolefin substrate is mesh.
4. The method of treating the surface of a medical device with a biomolecule of claim 3 wherein the polyolefin substrate is formed of polypropylene.
5. The method of treating the surface of a medical device with a biomolecule of claim 1 wherein the polyolefin substrate is formed of polypropylene and wherein the polyolefin substrate is a mesh.
6. The method of treating the surface of a medical device with a biomolecule of claim 1 wherein the polyolefin substrate forms a medical device in the form of sutures.
7. The method of treating the surface of a medical device with a biomolecule of claim 6 wherein the biomolecule is a growth factor.
8. The method of treating the surface of a medical device with a biomolecule of claim 1 wherein the polyolefin substrate forms a medical device in the form of one of a catheters and stent.
9. The method of treating the surface of a medical device with a biomolecule of claim 8 wherein the biomolecule is at least one of an anticoagulant, heparin, antithrombotic agent, and platelet agent.