Preventative vagal stimulation
The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.
1. A device for use in treating a patient using vagal stimulation comprising:
monitoring apparatus configured to monitor physiological parameters of a patient, wherein the monitoring apparatus comprises at least one electrode to monitor the electrical activity of the patient's heart;
a sensing module coupled to the monitoring apparatus and configured to receive the monitored physiological parameters;
a therapy delivery module configured to deliver electrical stimulation to the patient's vagus nerve; and
a control module coupled to the sensing module and to the therapy delivery module and configured to:
determine an increased risk of myocardial infarction or myocardial ischemia using the monitored physiological parameters,
determine an increase in sympathetic activity using the monitored physiological parameters, and
initiate delivery of preventative electrical stimulation to the patient's vagus nerve upon at least one indication of an increase in sympathetic activity and if an increased risk of myocardial infarction or myocardial ischemia is determined to decrease at least one of workload and inflammation of the patient's heart.
2. The device of claim 1 , wherein the control module is further configured to determine an increased risk of myocardial infarction or myocardial ischemia using the monitored physiological parameters by determining whether the electrical activity of the patient's heart comprises a ST-deviation.
3. The device of claim 1 , wherein the preventative electrical stimulation is controlled by a schedule programmed in memory to be delivered to the patient's vagus nerve more than once a day.
4. The device of claim 1 , wherein determining an increase in sympathetic activity comprises determining that the patient has awaken from sleep using the monitored physiological parameters.
5. The device of claim 1 , wherein the control module is further configured to adjust the preventative electrical stimulation delivered to the patient's vagus nerve based on an analysis of the monitored physiological parameters until the P-R intervals within the electrical activity of the patient's heart have increased to a level that reduces the workload of the patient's heart.
6. A method for use in treating a patient using vagal stimulation comprising:
monitoring physiological parameters of a patient, wherein the physiological parameters comprise the electrical activity of the patient's heart;
determining an increased risk of myocardial infarction or myocardial ischemia using the monitored physiological parameters;
determining an increase in sympathetic activity using the monitored physiological parameters; and
delivering preventative electrical stimulation to the patient's vagus nerve upon at least one indication of an increase in sympathetic activity and if an increased risk of myocardial infarction or myocardial ischemia is determined to decrease at least one of workload and inflammation of the patient's heart.
7. The method of claim 6 , wherein determining an increased risk of myocardial infarction or myocardial ischemia using the monitored physiological parameters comprises determining whether the electrical activity of the patient's heart comprises a ST-deviation.
8. The method of claim 6 , wherein the method further comprises delivering the preventative electrical stimulation one or more selected times per day set per a schedule.
9. The method of claim 6 , wherein determining an increase in sympathetic activity comprises determining that the patient has awaken from sleep.
10. The method of claim 6 , wherein the method further comprises adjusting the preventative electrical stimulation delivered to the patient's vagus nerve based on an analysis of the monitored physiological parameters until the P-R intervals within the electrical activity of the patient's heart have increased to a level that reduces the workload of the patient's heart.