Antibodies against human angiopoietin 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
1. A prokaryotic or eukaryotic host cell comprising: (A) an expression vector comprising a nucleic acid encoding a heavy chain of an antibody which binds specifically to human angiopoietin-2 (ANG-2), wherein the variable domain of said heavy chain comprises a CDR3 region having the sequence of SEQ ID NO: 1, a CDR2 region having the sequence of SEQ ID NO: 2, and a CDR1 region having the sequence of SEQ ID NO: 3; and (B) an expression vector comprising a nucleic acid encoding a light chain of said antibody, wherein the variable domain of said light chain comprises a CDR3 region having the sequence of SEQ ID NO: 4, a CDR2 region having the sequence of SEQ ID NO: 5, and a CDR1 region having the sequence of SEQ ID NO: 6.
2. A host cell according to claim 1 wherein said variable domain of said heavy chain has the sequence of SEQ ID NO: 7.
3. A host cell according to claim 1 wherein said variable domain of said light chain has the sequence of SEQ ID NO: 8.
4. A host cell according to claim 1 wherein said variable domain of said heavy chain has the sequence of SEQ ID NO: 7 and said variable domain of said light chain has the sequence of SEQ ID NO: 8.