Antibodies against human angiopoietin 2
The present invention relates to antibodies against human Angiopoietin 2 (anti-ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
1. An isolated antibody which binds specifically to human angiopoietin-2(ANG-2), wherein said antibody comprises:
(A) a heavy chain variable domain which comprises a CDR3 region having the sequence of SEQ ID NO: 33, a CDR2 region having the sequence of SEQ ID NO: 34 and a CDR1 region having the sequence of SEQ ID NO: 35;
(B) a light chain variable domain which comprises a CDR3 region having the sequence of SEQ ID NO: 36, a CDR2 region having the sequence of SEQ ID NO: 37 and a CDR1 region having the sequence of SEQ ID NO: 38.
2. An antibody according to claim 1 , comprising a heavy chain variable domain having the sequence of SEQ ID NO: 39; and a light chain variable domain having the sequence of SEQ ID NO: 40.
3. An antibody according to claim 1 wherein said antibody does not bind to human Angiopoietin 1 (ANG-1).
4. An antibody according to claim 1 wherein said antibody is of the human IgG4 subclass or the human IgG1 subclass.
5. A pharmaceutical composition comprising an antibody according to claim 1 or a fragment thereof.