Polymorphs of azabicyclohexane
The invention provides polymorphic crystalline forms of acid addition salts of (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane designated as polymorph form A, polymorph form B and polymorph form C, where polymorph form A is more thermodynamically stable than the other forms, methods for preparing and using such polymorph forms and pharmaceutical compositions containing such polymorph forms.
1. Crystalline (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride, wherein the (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane hydrochloride exhibits at least one of:
an X-ray powder diffraction pattern, as measured with Cu Kα radiation at crystal sizes of from about 10 to 40 microns, comprising peaks at about the following °2θ (degree) values:
17.14;
19.62;
21.96;
24.52;
and
26.74, or
a Raman spectrum comprising peaks at about the following wavenumbers (cm −1 ):
762;
836;
921;
959;
1393;
1597;
2890;
2982;
and
3064, substantially free of other geometric and optical isomers and polymorphic forms thereof.