IP Library › Granted Patent US 8,470,958
Granted Patent B1
US 8,470,958 · App. 13/367,965 · Granted Jun 25, 2013

Antibiotic-bound poly(caprolactone) polymer

Inventors: Edward Turos (Wesley Chapel, FL); Michelle Leslie (Tampa, FL)
Assignee: University of South Florida
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Quick Facts
Patent No.
US 8,470,958
App. No.
13/367,965
Granted
Jun 25, 2013
Kind
B1
Abstract

This invention is the design and synthesis of a caprolactone monomer which bears a pendant protected carboxyl group. This monomer has been copolymerized with caprolactone in varying ratios. After polymerization, the protecting group can be removed and an antibiotic can be attached as a new pendant group. The bioactivity of the antibiotic-bound poly(caprolactone) polymer is described.

Claims (8)

1. A homopolymer derived from polymerization of a single compound represented by the formula below:

wherein R1 is alkyl, R2 is an aryl, R3 is alkyl or aryl.

2. A homopolymer derived from polymerization of a single compound represented by the formula below:

wherein R1 is alkyl, R2 is an aryl.

3. A homopolymer derived from polymerization of a single compound represented by the formula below:

4. A homopolymer derived from polymerization of a single compound represented by the formula below:

5. A copolymer derived from polymerization of a plurality of compounds represented by the formulas below:

wherein R1 is alkyl, R2 is an aryl, R3 is alkyl or aryl.

Assignments (3)
CONFIRMATORY LICENSE Recorded Nov 5, 2013
From: UNIVERSITY OF SOUTH FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031579/0872 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 3, 2012
From: TUROS, EDWARD; LESLIE, MICHELLE
To: UNIVERSITY OF SOUTH FLORIDA
Reel/Frame 028149/0122 →
CONFIRMATORY LICENSE Recorded Apr 6, 2012
From: UNIVERSITY OF SOUTH FLORIDA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028003/0232 →
Continuity (2)
Division 11746704 · May 10, 2007
Provisional Application 60747061 · May 11, 2006