IP Library › Granted Patent US 8,673,300
Granted Patent B2
US 8,673,300 · App. 13/376,122 · Granted Mar 18, 2014

Therapeutic compositions and methods for the prevention of autoimmune diseases

Inventors: George Eisenbarth (Golden, CO); Li Zhang (Aurora, CO); John Kappler (Denver, CO); Brian Stadinski (N. Easton, MA)
Assignees: The Regents of the University of Colorado, a body corporate; National Jewish Health
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Quick Facts
Patent No.
US 8,673,300
App. No.
13/376,122
Granted
Mar 18, 2014
Kind
B2
Abstract

Antibodies specific for an MHC class II-autoantigen complex.

Claims (12)

1. An isolated antibody that specifically binds to a protein complex comprising I-A g7 Class II MHC molecule and a peptide selected from the group consisting of

SEQ ID NO:2 (VEALYLVCGERG),

SEQ ID NO:3 (VEALYLVCGER),

SEQ ID NO:8 (VERLYLVAGEE),

SEQ ID NO:4 (LREALYLVAE),

SEQ ID NO:5 (VRALYLVAGE),

SEQ ID NO:6 (ERLYLVAGEE),

SEQ ID NO:7 (ARYLVAGERE), and

SEQ ID NO:9 (EALYLVCGER).

2. The isolated antibody of claim 1 , wherein the antibody is humanized.

3. The isolated antibody of claim 1 , wherein the antibody is Fab, Fab′, F(ab′)2, or scFv fragment.

4. The isolated antibody of claim 1 , wherein the antibody is monoclonal.

Assignments (4)
CONFIRMATORY LICENSE Recorded Oct 31, 2017
From: UNIVERSITY OF COLORADO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044636/0014 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2012
From: EISENBARTH, GEORGE; ZHANG, LI; STADINSKI, BRIAN
To: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE
Reel/Frame 028158/0149 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 4, 2012
From: KAPPLER, JOHN
To: NATIONAL JEWISH HEALTH
Reel/Frame 028158/0155 →
CONFIRMATORY LICENSE Recorded Apr 24, 2012
From: UNIVERSITY OF COLORADO
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028093/0830 →
Continuity (2)
Provisional Application 61184106 · Jun 4, 2009
Related Publication 20120171212A1 · Jul 5, 2012