Substituted 4-hydroxypyrimidine-5-carboxamides
View Patent ↗The present invention relates to substituted 4-hydroxypyrimidine-5-carboxamides useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.
1. A compound selected from the group consisting of: (R)-4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide; (S) 4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide; 4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide; and a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 selected from the group consisting of: (R)-4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide and a pharmaceutically acceptable salt thereof.
3. A compound according to claim 1 selected from the group consisting of: (S)-4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide and a pharmaceutically acceptable salt thereof.
4. A compound selected from the group consisting of: 4-Hydroxy-N-[(6-methoxypyridin-3-yl)(tetrahydro-2H-pyran-4-yl)methyl]-2-pyridazin-3-ylpyrimidine-5-carboxamide; and a pharmaceutically acceptable salt thereof.