Cytoprotective agent
Disclosed is a cytoprotective agent for use with respect to ischemic damage, including as an active ingredient a triprenyl phenol compound represented by the following general formula (I), wherein X is —CHY—C(CH 3 ) 2 Z, Y and Z are each independently —H or —OH, or jointly form a single bond, and R represents a hydrogen atom or a substituent with a molecular weight of 1000 or less.
1. A method of treatment of cerebral hemorrhagic infarction, comprising the step of administering a drug containing a triprenyl phenol of formula (II) or formula (III) to a patient affected by cerebral hemorrhagic infarction:
wherein X 1 , X 2 and X 3 are each independently —CHY—C(CH 3 ) 2 Z; Y and Z are each independently —H or —OH, or jointly form a bond, and R 1 is selected from among any one of the following (A) through (C):
(A) a residue of an amino compound selected from the group consisting of a natural amino acid, a D-isomer of a natural amino acid, and a compound derived by replacing a carboxy group in a natural amino acid, or a D-isomer of a natural amino acid, with a hydrogen atom, a hydroxy group, or a hydroxymethyl group, from which one amino group has been removed, with the proviso that R 1 is not hydroxymethyl;
(B) an aromatic group having at least one selected from the group consisting of a carboxy group, a hydroxy group, a sulfonic group and a secondary amino group as a substituent or a part of a substituent, or an aromatic group that contains a secondary amino group and may contain a nitrogen atom; and
(C) an aromatic amino acid residue represented by the following formula (II-1)
wherein, in formula (II-1), n is 0 or 1, and R 3 is at least one substituent selected from the group consisting of a hydroxy group, a carboxy group, and a C1 to C5 alkyl group, wherein R 3 may be present or absent; and
wherein, in formula III, R 2 and the two nitrogens to which it is attached are derived from a diamine selected from the group consisting of: a natural amino acid with two amino groups; a D-isomer of a natural amino acid with two amino groups; a compound derived from a natural amino acid with two amino groups by replacing a carboxy group with a hydrogen atom, a hydroxy group, or a hydroxymethyl group; a compound derived from a D-isomer of a natural amino acid with two amino groups by replacing a carboxy group with a hydrogen atom, a hydroxy group, or a hydroxymethyl group; compounds having the formula H 2 N—CH(COOH)—(CH 2 ) n —NH 2 wherein n is an integer from 0 to 9; and compounds having the formula H 2 N—CH(COOH)—(CH 2 ) m —S p —(CH 2 ) q —CH(COOH)—NH 2 wherein m, p and q are each independently an integer from 0 to 9.
2. The method of treatment of cerebral hemorrhagic infarction according to claim 1 , wherein the triprenyl phenol compound is SMTP-7.
3. The method of treatment of cerebral hemorrhagic infarction according to claim 1 , wherein the patient is a patient with respect to whom treatment with a thrombolytic drug is contraindicated.
4. The method of treatment of cerebral hemorrhagic infarction according to claim 3 , wherein the triprenyl phenol compound is SMTP-7.