Pre-filled syringe including an oxygen absorber

1. A syringe for dispensing a drug, comprising:

a rigid syringe body containing the drug;

an oxygen absorbing material,

a separating element positioned between the drug and the oxygen absorbing material, the separating element preventing the drug from contacting oxygen absorbing material but allowing oxygen to pass from the drug to the oxygen absorbing material; and

an oxygen impermeable enclosure enclosing both the drug and the oxygen absorbing material, wherein the oxygen impermeable enclosure partially or fully forms the rigid syringe body or is held within the rigid syringe body.

2. A syringe according to claim 1 , wherein the oxygen impermeable enclosure is entirely within an outer surface of the rigid syringe body.

3. A syringe according to claim 1 , further comprising an inner container in contact with and enclosing the drug, wherein the inner container has greater oxygen permeability than the oxygen impermeable enclosure.

4. A syringe according to claim 3 , wherein the inner container is the separating element.

5. A syringe according to claim 4 , wherein the oxygen absorbing material is in gaseous communication with substantially the entire outer surface of the inner container.

6. A syringe according claim 3 , further comprising a plunger enclosed within the inner container.

7. A syringe according to claim 6 , wherein the oxygen absorbing material is positioned on an opposite side of the drug to the plunger.

8. A syringe according to claim 3 , wherein the inner container comprises cyclic olefin polymer material.

9. A syringe according to claim 1 , wherein the syringe is an autoinjector.

10. A syringe according to claim 1 , further comprising a needle through which the drug is dispensed from the syringe, wherein the needle is stored outside the oxygen impermeable enclosure prior to dispensing of the drug.

11. A syringe according to claim 1 , further comprising a needle through which the drug is dispensed from the syringe, wherein the needle is stored inside the oxygen impermeable enclosure prior to dispensing of the drug.

12. A syringe according to claim 1 , wherein the oxygen absorbing material is positioned on an opposite side of the drug to the needle.

13. A syringe according to claim 1 , further comprising a breaching mechanism forming part of the rigid syringe body, wherein the breaching mechanism includes a user actuated element and is configured on actuation of the user actuated element to breach the oxygen impermeable enclosure to allow the drug to be dispensed from the syringe.

14. A syringe according to claim 13 , wherein the breaching mechanism is configured so that operation of the breaching mechanism causes the drug to be dispensed from the syringe.

15. A syringe according to claim 13 , further comprising a needle through which the drug is dispensed from the syringe, wherein the breaching mechanism is configured so that operation of the breaching mechanism puts the needle in fluid communication with the drug.

16. A syringe according to claim 13 , wherein the oxygen absorbing material is shaped to allow the passage of a part of the breaching mechanism therethrough.

17. A syringe according to claim 13 , wherein the oxygen impermeable enclosure includes an oxygen impermeable seal, wherein the breaching mechanism is configured to breach the seal on actuation of the user actuated element.

18. A syringe according to claim 17 , wherein the oxygen-impermeable seal comprises aluminium, a polyamide, a fluorocarbon or Ethylene Vinyl Alcohol.

19. A method of manufacturing a syringe comprising a rigid syringe body, an inner container enclosing a drug, an oxygen absorbing material, the inner container preventing the oxygen absorbing material from contacting the drug but allowing oxygen to pass from the drug to the oxygen absorbing material, and an oxygen impermeable enclosure enclosing both the inner container and the oxygen absorbing material, wherein the oxygen impermeable enclosure partially or fully forms the rigid syringe body or is held within the rigid syringe body, comprising the steps of:

filling the inner container with the drug and sealing the inner container in an aseptic or low particulate environment,

placing the oxygen absorbing material and the inner container into the oxygen impermeable enclosure in a different environment which is isolated from the first environment, and

sealing the oxygen impermeable enclosure.

20. A method according to claim 19 , wherein the oxygen absorbing material is placed in the oxygen impermeable enclosure after the filled and sealed inner container.