Lactic acid bacteria and bifidobacteria for treating endotoxemia
View Patent ↗The invention relates to use of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof for treating metabolic endotoxemia, inhibiting bacterial translocation and regulating lipid absorption in a mammal.
1. A method of treating metabolic endotoxemia in a mammal in need thereof, the method comprising administering an effective amount of a bacterium selected from a lactic acid bacterium, a Bifidobacterium or a mixture of any thereof, wherein the metabolic endotoxemia is induced by a high fat diet.
2. A method according to claim 1 , wherein the endotoxemia comprises an increase of the level of lipopolysaccharides in the mammal by a factor in the range from 2 to 4 compared with basal lipopolysaccharide levels.
3. A method according to claim 1 , wherein the bacterium is a probiotic lactic acid bacterium and/or a probiotic Bifidobacterium.
4. A method according to any claim 1 , wherein the bacterium is a bacterium selected from the genera Lactobacillus or Bifidobacterium and mixtures thereof.
5. A method according to claim 4 , wherein the bacterium is selected from the species Lactobacillus acidophilus, Lactobacillus plantarum, Bifidobacterium animalis, Bifidobacterium lactis , or Bifidobacterium bifidium , and mixtures thereof.
6. A method according to claim 5 , wherein the bacterium is Lactobacillus acidophilus strain NCFM, Bifidobacterium animalis subsp. lactis strain 420 , Lactobacillus salivarius strain 33, or a mixture thereof.
7. A method according to claim 1 , wherein the mammal is diabetic and obese.
8. A method according to claim 1 , wherein the mammal is diabetic and non-obese.
9. A method according to claim 1 , wherein the mammal is non-diabetic and obese.
10. A method according to claim 1 , wherein the mammal continues to ingest a high-fat diet during the course of the treatment.
11. A method according to claim 1 , wherein the bacterium is administered in combination with one or more prebiotics.
12. A method according to claim 11 , wherein the prebiotic is selected from alginate, xanthan, pectin, locust bean gum, inulin, guar gum, a galacto-oligosaccharide, a fructo-oligosaccharide, polydextrose, lactitol, lactosucrose, a soybean oligosaccharide, palatinose, an isomalto-oligosaccharide, a gluco-oligosaccharide or a xylo-oligosaccharide, or a mixture of any thereof.
13. A method according to claim 12 , wherein the prebiotic is polydextrose.
14. A method according to claim 1 , wherein the endotoxemia comprises an increase of the level of lipopolysaccharides in the mammal by a factor in the range from 1.5 to 20 compared with basal lipopolysaccharide levels.