Methods of treating hematologic cancers
View Patent ↗This disclosure relates to the treatment of hematologic cancers, for example, cancers of the blood, by methods that include administration of EGCG and at least one of a purine nucleoside analog and an alkylating agent. In particular, methods of treating chronic lymphocytic leukemia (CLL) and acute lymphocytic leukemia (ALL) are described.
1. A method of treating a hematologic cancer in a subject having a hematologic cancer comprising the steps of:
(a) administering to the subject an effective amount of epigallocatechin gallate (EGCG), or a pharmaceutically acceptable salt, ester, or salt of an ester thereof; and
(b) administering to the subject an effective amount of fludarabine, or a pharmaceutically acceptable salt, ester, or salt of an ester thereof, and chlorambucil, or a pharmaceutically acceptable salt, ester, or salt of an ester thereof.
2. The method of claim 1 , wherein the EGCG, fludarabine, and chlorambucil are admixed prior to administration.
3. The method of claim 1 , wherein the EGCG and the chlorambucil are admixed prior to administration.
4. The method of claim 1 , wherein the EGCG and the fludarabine are admixed prior to administration.
5. The method of claim 1 , wherein the EGCG and at least one of the fludarabine and the chlorambucil are administered concurrently.
6. The method of claim 1 , wherein the fludarabine and the chlorambucil are admixed prior to administration.
7. The method of claim 1 , wherein the EGCG and at least one of the fludarabine and the chlorambucil are administered sequentially.
8. The method of claim 1 , wherein the hematologic cancer is chosen from chronic lymphocytic leukemia and acute lymphoblastic leukemia.
9. A method of treating chronic lymphocytic leukemia in a subject having a hematologic cancer, the method comprising administering to the subject a composition comprising EGCG, or a pharmaceutically acceptable salt, ester, or salt of an ester thereof, flurdarabine, or a pharmaceutically acceptable salt, ester, or salt of an ester thereof, and chlorambucil, or a pharmaceutically acceptable salt, ester, or salt of an ester thereof.