Treatment of cancer using the sodium salt of a benzoic acid derivative
The present invention provides a method of treating cancer using the sodium salt of a benzoic acid derivative, alone or in combination with standard treatments such as chemotherapy and radiotherapy.
1. A method of treating cancer in a mammal, wherein said method comprises administering, to a mammal in need of such treatment, a therapeutically effective amount of a sodium salt of a compound having the structure:
2. The method of claim 1 , wherein the the sodium salt of the compound is administered in combination with a chemotherapeutic compound.
3. The method of claim 1 , wherein the sodium salt of the compound is administered in combination with ionizing radiation.
4. The method of claim 1 , wherein the cancer is selected from the group consisting of melanoma, breast carcinoma and lung carcinoma.
5. The method of claim 1 , wherein the mammal is a human.
6. The method of claim 5 , wherein the cancer is melanoma.
7. The method of claim 5 , wherein the cancer is breast carcinoma.
8. The method of claim 5 , wherein the cancer is lung carcinoma.
9. The method of claim 1 , wherein the sodium salt of the compound is administered in combination with an effective amount of paclitaxel.
10. A pharmaceutical composition comprising:
(a) a therapeutically effective amount of a sodium salt of a compound having the structure:
and
(b) at least one pharmaceutically acceptable carrier or excipient.
11. The pharmaceutical composition of claim 10 , wherein the composition is suitable for oral administration to a mammal.
12. The pharmaceutical composition of claim 10 , wherein the composition is suitable for parenteral administration to a mammal.
13. The pharmaceutical composition of claim 10 , wherein the composition is suitable for intravenous administration to a mammal.
14. A method of treating cancer in a mammal, wherein said method comprises administering, to a mammal in need of such treatment, a therapeutically effective amount of a compound having the structure:
15. A pharmaceutical composition which comprises:
(a) a therapeutically effective amount of a compound having the structure
and
(b) at least one pharmaceutically acceptable carrier or excipient.
16. A sodium salt of a compound having the structure:
17. A compound having the structure: