Nano-enhanced evanescence integrated technique (NEET) based microphotonic device and sample analysis system
A device, a method of fabricating the device and a sample analysis system that includes the device are provided. The device includes an optical waveguide having a plurality of nanofeatures integrated thereon to influence at least one of evanescence and coupling of an optical field of the optical waveguide. The sample analysis system includes a fluidic actuation system for introducing sample specimen fluid into a microfluidic channel of the device for evanescence based detection.
1. A device comprising:
an optical rib waveguide having a plurality of nanofeatures integrated thereon to influence at least one of evanescence and coupling of an optical field of the optical rib waveguide; and
a microfluidic channel in contact with at least one side of the optical rib waveguide.
2. The device of claim 1 , wherein at least some of the plurality of nanofeatures have a different or same refractive index as that of any layer of the optical rib waveguide.
3. The device of claim 1 , wherein the plurality of nanofeatures are formed such that they increase surface binding of bio-specimens on the optical rib waveguide.
4. The device of claim 1 , wherein the optical rib waveguide is substantially transparent to light in the visible or infrared spectrum.
5. The device of claim 1 , wherein the nanofeatures comprise at least one of: nanoparticles, nanopillars, nanocavities, nanotubes, nanorods, nanofilms, nanocolloids, nanostructures and nanospheres.
6. The device of claim 1 , wherein the plurality of nanofeatures comprises at least one row of nanofeatures arranged substantially transverse to a direction of propagation of light through the optical rib waveguide.
7. The device of claim 6 , wherein the at least one row of nanofeatures comprises a plurality of rows of nanofeatures, the plurality of rows being equally spaced or randomly distributed apart along a length of the optical rib waveguide.
8. The device of claim 1 , wherein the optical rib waveguide comprises a first side wall, a second side wall opposite the first side wall and a top side wall joining the first side wall and the second side wall.
9. The device of claim 1 , wherein the device is fabricated on Silicon, Silica, Silicon-On-Insulator (SOI), InP, GaAs, Poly dimethylsiloxane (PDMS), Poly Methyl Methacrylate (PMMA), SU8, other optical polymers and materials, or a combination thereof.
10. The device of claim 8 , wherein each side of the optical rib waveguide in contact with the microfluidic channel has nanofeatures of the plurality of nanofeatures integrated thereon.
11. The device of claim 1 , further comprising a seal top defining a bound of the microfluidic channel.
12. The device of claim 11 , wherein the seal top comprises:
an inlet port for delivery of a sample specimen fluid into the microfluidic channel; and
an outlet port for removal of the sample specimen fluid from the microfluidic channel.
13. The device of claim 1 , wherein the microfluidic channel comprises a plurality of microfluidic channels.
14. A sample analysis system comprising:
the device of claim 1 ; and
a fluidic actuation system for introducing sample specimen fluid into the microfluidic channel, wherein the fluidic actuation system comprises a pumping configuration including a mechanical or non-mechanical micropump or digital microfluidic system for fluid actuation.
15. A sample analysis system comprising:
the device of claim 1 ;
a fluidic actuation system for introducing sample specimen fluid into the microfluidic channel;
a light source for inputting light into an input end of the optical waveguide; and
a spectrum analyzer for determining an insertion loss of the optical waveguide.
16. A method of fabricating a device, the method comprising:
microfabricating an optical rib waveguide on a semiconductor material platform;
microfabricating a plurality of nanofeatures on at least one surface of the optical rib waveguide to influence at least one of evanescence and coupling of an optical field of the optical rib waveguide; and
microfabricating a microfluidic channel on the semiconductor material platform such that the microfluidic channel is in contact with the optical rib waveguide.
17. The method of claim 16 , wherein microfabricating a plurality of nanofeatures on at least one surface of the optical rib waveguide comprises microfabricating at least some of the plurality of nanofeatures with a material having a different or same refractive index as that of any layer of the optical rib waveguide.
18. The method of claim 16 , wherein microfabricating the optical rib waveguide comprises microfabricating the optical rib waveguide from a material that is substantially transparent to light in the visible or infrared spectrum.
19. The method of claim 16 , wherein microfabricating a plurality of nanofeatures on at least one surface of the optical rib waveguide comprises microfabricating at least one of: nanoparticles, nanopillars, nanocavities, nanotubes, nanorods, nanofilms, nanocolloids, nanostructures and nanospheres, on the at least one surface of the optical rib waveguide.
20. The method of claim 16 , wherein microfabricating the optical rib waveguide comprises microfabricating the optical rib waveguide having a first side wall, a second side wall opposite the first side wall and a top side wall joining the first side wall and the second side wall.