IP Library › Granted Patent US 8,415,297
Granted Patent B2
US 8,415,297 · App. 13/398,887 · Granted Apr 9, 2013

Aminotetrahydropyrans as dipeptidyl peptidase-IV inhibitors for the treatment or prevention of diabetes

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Quick Facts
Patent No.
US 8,415,297
App. No.
13/398,887
Granted
Apr 9, 2013
Kind
B2
Abstract

The present invention is directed to novel substituted aminotetrahydropyrans of structural formula I which are inhibitors of the dipeptidyl peptidase-IV enzyme and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Claims (7)

1. A pharmaceutical composition which comprises a compound

which is:

and a pharmaceutically acceptable carrier, wherein the pharmaceutical composition is in the form of a tablet.

2. The pharmaceutical composition of claim 1 , wherein the pharmaceutically acceptable carrier is microcrystalline cellulose.

3. The pharmaceutical composition of claim 1 additionally comprising atorvastatin.

4. The pharmaceutical composition of claim 1 , additionally comprising a CETP inhibitor.

5. The compound which is:

Assignments (1)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →