Compositions Comprising Peroxy alpha-Ketocarboxylic Acid and Methods For Producing and Using the Same
The present invention provides compositions comprising peroxy α-ketocarboxylic acid and methods for using the same. In some particular embodiments, compositions of the invention also include α-ketoesters.
1 . A composition comprising a mixture of an α-ketoester and a peroxy α-ketocarboxylic acid (PKCA).
2 . The composition of claim 1 , wherein said mixture further comprises an α-ketoacid.
3 . The composition of claim 2 , wherein said α-ketoacid is a decarboxylated α-ketoacid of said PKCA.
4 . The composition of claim 1 , wherein said α-ketoester comprises an alkyl α-ketoester.
5 . The composition of claim 4 , wherein said alkyl α-ketoester is an alkyl pyruvate ester.
6 . The composition of claim 1 , wherein the molar ratio of said α-ketoester to said PKCA is from about 0.02:1 to about 10:1.
7 . The composition of claim 1 , wherein said PKCA comprises peroxy α-ketopyruvic acid, peroxy α-ketobutyric acid, peroxy α-ketovaleric acid, or a mixture thereof.
8 . The composition of claim 1 , wherein said composition is formulate as a gel, a liquid, lotion, skin patch, irrigation gel, a spray, a dressing, a film, beads, a disc, a fabric, a fiber or a combination thereof.
9 . A method for reducing the amount of microorganism on a surface, said method comprising contacting the surface with a composition comprising an effective amount of a mixture of an α-ketoester and a peroxy α-ketocarboxylic acid.
10 . The method of claim 9 , wherein the microorganism comprises vegetative bacteria.
11 . The method of claim 9 , wherein the microorganism comprises bacterial spores, mycobacteria, gram-negative bacteria, vegetative gram-positive bacteria, virus, or a combination thereof.
12 . A method for reducing the number of infectious vegetative bacteria on a substrate, said method comprising contacting the substrate with a composition comprising an effective amount of a mixture of an α-ketoester and a peroxy α-ketocarboxylic acid.
13 . A method for preventing and/or reducing microbial-related diseases in a mammal that result from the mammal's contact with a microbial infected substrate, said method comprising contacting the substrate with a composition comprising an effective amount of a mixture of an α-ketoester and a peroxy α-ketocarboxylic acid.
14 . A method for treating wound in a subject, said method comprising topically administering a composition comprising a peroxy α-ketocarboxylic acid to the wound area of the subject.
15 . The method of claim 14 , wherein the composition further comprises an α-ketoester.
16 . A method for preventing sepsis from a wound in a subject, said method comprising topically administering a composition comprising an effective amount of a peroxy α-ketocarboxylic acid to the wound of the subject.
17 . The method of claim 16 , wherein the composition further comprises an α-ketoester.
18 . A composition consisting essentially of a peroxy α-ketocarboxylic acid (PKCA), an α-ketoester, optionally the parent carboxylic acid of PKCA and/or a salt thereof, optionally a decarboxylated derivative of PKCA, and optionally hydrogen peroxide.
19 . A method for reducing microorganism in a biofilm, said method comprising contacting the biofilm with an effective amount of composition comprising a peroxy α-ketocarboxylic acid (PKCA), an α-ketoester, or a combination thereof.
20 . The method of claim 19 , wherein the composition further comprises a parent carboxylic acid of PKCA and/or a salt thereof, a decarboxylated derivative of PKCA, hydrogen peroxide, or a combination thereof.