Azabicycloalkane derivatives, preparation thereof and use thereof in therapy
View Patent ↗The invention relates to compounds of the general formula (I): wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
1. A compound of the formula (I):
in which:
R represents hydrogen, halogen, hydroxyl, (C 1 -C 6 )alkoxy, (C 3 -C 7 )cycloalkyl-O—, (C 3 -C 7 )cycloalkyl-(C 1 -C 3 )alkylene-O—,
or a heterocycloalkyl, aryl or heteroaryl group; wherein said group is optionally substituted by one or more groups chosen from halogen, (C 1 -C 6 )alkyl, (C 3 -C 7 )cycloalkyl, (C 3 -C 7 )cycloalkyl-(C 1 -C 3 )alkylene, (C 1 -C 6 )alkoxy, (C 3 -C 7 )cycloalkyl-O—, (C 3 -C 7 )cycloalkyl-(C 1 -C 3 )alkylene-O—, (C 1 -C 6 )fluoroalkyl, (C 1 -C 6 )fluoroalkoxy, nitro, cyano, hydroxyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, heterocycloalkyl, aryl, aryl-(C 1 -C 6 )alkylene, heteroaryl, heteroaryl-(C 1 -C 6 )alkylene, aryl-O— or —C(O)—(C 1 -C 6 )alkyl groups, the heterocycloalkyl group optionally being substituted by —C(O)O(CH 3 ) 3 ;
n represents 2;
m represents 2; and
o represents 1;
or a salt thereof.
2. The compound of formula (I) according to claim 1 ,
wherein:
R represents hydrogen, halogen, hydroxyl,
or a heterocycloalkyl, aryl or heteroaryl group; wherein said group is optionally substituted by one or more groups chosen from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )fluoroalkyl, (C 1 -C 6 )fluoroalkoxy, nitro, cyano, hydroxyl, amino, (C 1 -C 6 )alkylamino, di(C 1 -C 6 )alkylamino, heterocycloalkyl, aryl, aryl-(C 1 -C 6 )alkylene, heteroaryl, aryl-O— or —C(O)—(C 1 -C 6 )alkyl groups, the heterocycloalkyl group optionally being substituted by —C(O)O(CH 3 ) 3 ;
n represents 2;
m represents 2; and
o represents 1;
or a salt thereof.
3. The compound of formula (I) according to claim 1 ,
wherein:
R represents halogen, hydroxyl,
or a heterocycloalkyl group or an aryl group or a heteroaryl group; wherein said group is optionally substituted by one or more groups chosen from halogen, (C 1 -C 6 )alkyl, (C 1 -C 6 )alkoxy, (C 1 -C 6 )fluoroalkyl, (C 1 -C 6 )fluoroalkoxy, di(C 1 -C 6 )alkylamino, heterocycloalkyl, aryl, aryl-(C 1 -C 6 )alkylene, heteroaryl, aryl-O— or —C(O)—(C 1 -C 6 )alkyl groups; the heterocycloalkyl group optionally being substituted by —C(O)O(CH 3 ) 3 ;
n represents 2;
m represents 2; and
o represents 1;
or a salt thereof.
4. The compound of formula (I) according to claim 1 , wherein n and m are 2 and o is 1 or a salt thereof.
5. A pharmaceutical composition comprising a compound of formula (I) according to claim 1 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.
6. A pharmaceutical composition comprising a compound of formula (I) according to claim 2 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.
7. A pharmaceutical composition comprising a compound of formula (I) according to claim 3 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.
8. A pharmaceutical composition comprising a compound of formula (I) according to claim 4 or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable excipient.