IP Library Granted Patent US 8,516,610
Granted Patent B1
US 8,516,610 · App. 13/423,317 · Granted Aug 20, 2013

High-frequency rheology system

Inventors: Hadi Tavakoli Nia (Cambridge, MA); Iman Soltani Bozchalooi (Cambridge, MA); Kamal Youcef-Toumi (Cambridge, MA); Christine Ortiz (Melrose, MA); Alan J. Grodzinsky (Lexington, MA); Eliot Frank (Cambridge, MA)
Assignee: Massachusetts Institute of Technology
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Quick Facts
Patent No.
US 8,516,610
App. No.
13/423,317
Granted
Aug 20, 2013
Kind
B1
Abstract

Rheology system. The system includes a first piezoelectric actuator assembly for providing microscale displacement of a sample and a second piezoelectric actuator assembly for oscillating the sample at a nano/micro scale displacement in a selected frequency range extended significantly as compared to the frequency range available on the commercial AFMs. A preferred sample is cartilage and the disclosed system can distinguish between normal cartilage and GAG-depleted cartilage.

Claims (12)

1. A rheology system comprising:

a first piezoelectric actuator assembly for providing microscale displacement of a sample; and

a second piezoelectric actuator assembly for oscillating the sample at a nanoscale/microscale displacement in a selected frequency range wherein the second piezoelectric actuator assembly comprises:

a beam for supporting the sample;

a substrate to which the beam is affixed in a spaced-apart relation; and

a piezoelectric actuator positioned between the substrate and the beam to cause the beam to oscillate at a selected frequency and displacement upon piezoelectric actuator actuation.

2. The system of claim 1 wherein the second piezoelectric actuator is pre-loaded against the beam.

3. The system of claim 1 wherein the selected frequency is in the range of 1 Hz to 200 kHz.

4. The system of claim 1 wherein the nanoscale displacement is approximately 1 nm.

5. The system of claim 1 wherein the beam is made of carbon fiber.

6. The system of claim 1 further including a mica layer between the beam and the sample.

7. The system of claim 1 wherein the sample is cartilage.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 11, 2013
From: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031202/0587 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 24, 2012
From: TAVAKOLI NIA, HADI; SOLTANI BOZCHALOOI, IMAN; YOUCEF-TOUMI, KAMAL; ORTIZ, CHRISTINE; GRODZINSKY, ALAN J.; FRANK, ELIOT
To: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
Reel/Frame 028096/0521 →