Methods and assays for treating subjects with SHANK3 deletion, mutation or reduced expression
Methods and assays are disclosed for treating subjects with 22q13 deletion syndrome or SHANK3 deletion or duplication, mutation or reduced expression, where the methods comprise administering to the subject insulin-like growth factor 1 (IGF-1), IGF-1-derived peptide or analog, growth hormone, an AMPAkine, a compound that directly or indirectly enhances glutamate neurotransmission, including by inhibiting inhibitory (most typically GABA) transmission, or an agent that activates the growth hormone receptor or the insulin-like growth factor 1 (IGF-1) receptor, or a downstream signaling pathway thereof.
1. A method for treating a human subject with Phelan-McDermid Syndrome comprising administering insulin-like growth factor 1 (IGF-1) to the human subject in an amount and manner effective to alleviate a motor deficit.