Chemical Compounds 572
Compounds of formula (I): The present invention relates to novel indazolyl ester or amide derivatives, to pharmaceutical compositions comprising such derivatives, to processes for preparing such novel derivatives and to the use of such derivatives as medicaments
1 . A compound of formula (I):
wherein:
A is C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 cyanoalkyl, cyano, C 1-6 nitroalkyl, nitro, C 1-6 alkylS(O) n , C 1-6 alkoxy, C 3-7 cycloalkylC 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 3-7 heterocycloalkylC 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkylC 1-6 thioalkyl, C 1-6 thioalkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkylOC 1-6 alkylOC 1-6 alkyl, C 1-6 alkylOC 1-6 alkylO, C 1-6 alkylC(O)C 1-6 alkyl, C 1-6 alkylC(O), C 1-6 alkylC(O)OC 1-6 alkyl, C 1-6 alkylC(O)O, C 1-6 alkylOC(O)C 1-6 alkyl, C 1-6 alkylOC(O), HOC(O), NR 5 R 6 C 1-6 alkyl, NR 5 R 6 , NR 5 R 6 C(O)C 1-6 alkyl, NR 5 R 6 C(O), NR 5 R 6 OC(O)C 1-6 alkyl, NR 5 R 6 OC(O), R 7 NH, C 5-10 arylC 1-3 alkyl, C 5-10 aryl, C 5-10 heteroarylC 1-3 alkyl or C 5-10 heteroaryl, whereby the cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be optionally substituted by one or more substituents independently selected from halo, cyano, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 alkylOC(O), C 1-4 alkylOC 1-4 alkyl, C 1-4 alkylS(O) 2 and C 1-4 haloalkylO, and R x is hydrogen, or
A forms together with R x a 5 to 6 membered azacyclic ring optionally having one or more further heteroatoms independently selected from O, N and S;
R 1 and R 1a are independently selected from hydrogen, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 alkylOC 1-4 alkyl, C 1-4 alkylC 1-4 thioalkyl and C 1-4 haloalkyl, or R 1 and R 1a together are oxo;
R 2 is hydrogen or C 1-4 alkyl;
R 3 is C 5-10 aryl, C 5-10 arylC 1-4 alkyl, C 5-10 arylO, C 5-10 arylOC 1-4 alkyl or C 5-10 heteroaryl, which may be optionally substituted by one or more substituents independently selected from B;
B is C 1-3 hydroxyalkyl, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylC 1-4 thioalkyl, C 1-4 thioalkyl, C 3-6 cycloalkylC 1-4 thioalkyl, C 3-6 cycloalkylS, C 1-3 alkylS(O) n C 1-4 alkyl, C 1-3 alkylS(O) n , C 1-4 haloalkyl, C 1-4 haloalkylO, halo, nitro, cyano, C 1-4 alkylOC 1-4 alkylOC 1-4 alkyl, C 1-4 alkylC(O)C 1-4 alkyl, C 1-4 alkylC(O), C 1-4 alkylC(O)OC 1-4 alkyl, C 1-4 alkylC(O)O, C 1-4 alkylOC(O)C 1-4 alkyl, C 1-4 alkylOC(O), NR 8 R 9 C 1-4 alkyl, NR 8 R 9 , NR 8 R 9 C(O)C 1-4 alkyl, NR 8 R 9 C(O), NR 8 R 9 OC(O)C 1-4 alkyl, NR 8 R 9 OC(O), NR 8 R 9 C(O)OC 1-4 alkyl, NR 8 R 9 C(O)O, R 9 C(O)R 8 NC 1-4 alkyl, R 9 C(O)R 8 NH, C 1-4 alkylNH, C 1-4 alkylOC(O)NH, C 1-4 alkylC(O)OC 1-4 alkylNH, C 1-4 alkylC(O)C 1-4 alkylNH, C 1-4 alkylC(O)NH, NR 8 R 9 S(O) n C 1-4 alkyl or NR 8 R 9 S(O) n ;
n is 1 or 2;
R 4 is hydrogen, hydroxy, halo, C 1-4 alkyl or C 1-4 haloalkyl;
W is hydrogen, or
phenyl, C 1-4 alkyl, C 3-7 cycloalkyl, thienyl, isoxazolyl, pyrazolyl, pyridinyl, pyridazinyl or pyrimidinyl all of which are optionally substituted by one or more substituents independently selected from C 1-3 hydroxyalkyl, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylC 1-4 thioalkyl, C 1-4 thioalkyl, C 3-6 cycloalkylC 1-4 thioalkyl, C 3-6 cycloalkylS, C 3-6 cycloalkyl, C 3-6 cycloalkylC 1-4 alkyl, C 3-6 heterocycloalkyl, C 3-6 heterocycloalkylC 1-4 alkyl, C 1-4 alkylS(O) n C 1-4 alkyl, C 1-4 alkylS(O) n , C 1-4 haloalkyl, C 1-4 haloalkylO, halo, nitro, cyano, C 1-4 alkylOC 1-4 alkyl, C 1-4 alkylOC 1-4 alkylOC 1-4 alkyl, C 1-4 alkylC(O)C 1-4 alkyl, C 1-4 alkylC(O), C 1-4 alkylC(O)OC 1-4 alkyl, C 1-4 alkylC(O)O, C 1-4 alkylOC(O)C 1-4 alkyl, C 1-4 alkylOC(O), NR 10 R 11 C 1-4 alkyl, NR 10 R 11 , NR 10 R 11 C(O)C 1-4 alkyl, NR 10 R 11 C(O), NR 10 R 11 C(O)OC 1-4 alkyl, NR 10 R 11 C(O)O, NR 10 R 11 OC(O)C 1-4 alkyl, NR 10 R 11 OC(O), R 11 C(O)R 10 NC 1-4 alkyl, R 11 C(O)R 10 NH, C 1-4 alkylOC(O)C 1-4 alkylNH, C 1-4 alkylOC(O)NH, C 1-4 alkylC(O)OC 1-4 alkylNH, C 1-4 alkylC(O)C 1-4 alkylNH, C 1-4 alkylC(O)NH, NR 10 R 11 S(O) n C 1-4 alkyl or NR 10 R 11 S(O) n ;
X is CH 2 , O, S, S(O) n , NH or NC 1-4 alkyl;
Y is hydrogen, halo, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 thioalkyl, C 1-4 haloalkyl, C 1-4 haloalkylO, nitro, cyano, hydroxy, R 12 C(O), R 12 OC(O), R 12 C(O)O, C 1-6 alkylS(O) n , R 12 R 13 NS(O) n , benzyloxy, imidazolyl, C 1-4 alkylNHC(O), NR 12 R 13 C(O), C 1-4 alkylC(O)NH or NR 12 R 13 ;
Z is O or S;
R 5 , R 6 , R 8 , R 9 , R 10 , R 11 , R 12 and R 13 are independently selected from hydrogen, C 1-6 alkylC(O), NHR 7 C(O) and C 1-6 alkyl; and
R 7 is hydrogen, C 1-6 alkyl, C 1-6 alkylC(O)OC 1-3 alkyl, C 1-6 alkylC(O)O, C 1-6 alkylOC(O)C 1-3 alkyl, C 1-6 alkylOC(O), C 1-6 alkylC(O), C 5-10 heteroarylC 1-3 alkyl, C 5-10 heteroaryl, C 5-10 arylC 1-3 alkyl, C 5-10 aryl, C 3-6 cycloalkylC 1-3 alkyl or C 3-6 cycloalkyl;
or a pharmaceutically acceptable salt thereof.
2 . The compound according to claim 1 , wherein:
A is C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 1-6 haloalkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkylOC 1-6 alkylOC 1-6 alkyl, C 1-6 alkylC(O)OC 1-6 alkyl, C 1-6 alkylOC(O), HOC(O), NR 5 R 6 C 1-6 alkyl, NR 5 R 6 C(O), NR 5 R 6 OC(O), R 7 NH, C 5-10 arylC 1-3 alkyl, C 5-10 aryl or C 5-10 heteroaryl, whereby the cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be optionally substituted by one or more substituents independently selected from halo, cyano, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 alkylOC(O), C 1-4 alkylOC 1-4 alkyl and C 1-4 alkylS(O) 2 and R x is hydrogen, or
A forms together with R x a 5 membered azacyclic ring optionally having one or more further heteroatoms independently selected from O and N;
R 1 and R 1a are independently selected from hydrogen, C 1-4 alkyl, C 1-4 hydroxyalkyl, C 1-4 alkylOC 1-4 alkyl and C 1-4 haloalkyl, or R 1 and R 1a together are oxo;
R 2 is hydrogen or C 1-4 alkyl;
R 2 is hydrogen;
R 3 is C 5-10 aryl, C 5-10 arylC 1-4 alkyl, C 5-10 arylO, C 5-10 arylOC 1-4 alkyl or C 5-10 heteroaryl, which may be optionally substituted by one or more substituents independently selected from B;
B is hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylC 1-4 thioalkyl, C 1-4 thioalkyl, C 3-6 cycloalkylS, C 1-3 alkylS(O) n C 1-4 alkyl, C 1-3 alkylS(O) n , C 1-4 haloalkyl or halo;
n is 1 or 2;
R 4 is hydrogen;
W is phenyl, C 1-4 alkyl, C 3-7 cycloalkyl, pyridinyl, pyridazinyl or pyrimidinyl all of which are optionally substituted by one or more substituents independently selected from C 1-3 hydroxyalkyl, C 3-6 heterocycloalkylC 1-4 alkyl, halo, C 1-4 alkylOC(O) and NR 10 R 11 C 1-4 alkyl;
X is O or S;
Y is hydrogen, halo or C 1-4 alkyl;
Z is O or S;
R 5 , R 6 , R 10 and R 11 are independently selected from hydrogen, C 1-6 alkylC(O), NHR 7 C(O) and C 1-6 alkyl; and
R 7 is hydrogen, C 1-6 alkyl, C 1-6 alkylOC(O)C 1-3 alkyl, C 5-10 heteroarylC 1-3 alkyl or C 3-6 cycloalkyl;
or a pharmaceutically acceptable salt thereof.
3 . The compound according to claim 1 , wherein:
A is C 1-3 hydroxyalkyl, C 3-5 cycloalkyl, C 1-3 haloalkyl or NR 5 R 6 C(O);
R 1 and R 1a are independently selected from hydrogen and C 1-3 alkyl;
R 2 is hydrogen;
R 3 is C 5-10 aryl C 5-10 arylOC 1-2 alkyl or C 5-10 heteroaryl, which may be optionally substituted by one or more substituents independently selected from B;
B is C 1-3 alkoxy or C 1-3 alkylS(O) n ;
n is 2;
R 4 is hydrogen;
W is phenyl which is optionally substituted by one or more halo;
X is O;
Y is hydrogen;
Z is O;
R 5 and R 6 are independently selected from hydrogen and C 1-3 alkyl; and
R x is hydrogen;
or a pharmaceutically acceptable salt thereof.
4 . The compound according to any claim 1 wherein:
R 2 is hydrogen; R 4 is hydrogen; X is O; Y is hydrogen; and Z is O.
5 . The compound according to claim 1 wherein R 1 , R 1a , R 2 , R 3 , R 4 , R 5 , R 6 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R x Y, W and n are as defined in claim 1 , and A is R 7 NH, wherein R 7 is hydrogen, C 1-6 alkyl, C 1-6 alkylOC(O)C 1-3 alkyl, C 5-10 heteroarylC 1-3 alkyl or C 3-6 cycloalkyl.
6 . The compound according to claim 1 wherein
A is C 1-6 alkyl, C 1-6 hydroxyalkyl, C 1-6 alkoxy, C 3-7 cycloalkyl, C 3-7 heterocycloalkyl, C 1-6 haloalkyl, C 1-6 alkylOC 1-6 alkyl, C 1-6 alkylOC 1-6 alkylOC 1-6 alkyl, C 1-6 alkylC(O)OC 1-6 alkyl, C 1-6 alkylOC(O), HOC(O), NR 5 R 6 C 1-6 alkyl, NR 5 R 6 C(O), NR 5 R 6 OC(O), R 7 NH, C 5-10 arylC 1-3 alkyl, C 5-10 aryl or C 5-10 heteroaryl, whereby the cycloalkyl, heterocycloalkyl, aryl or heteroaryl may be optionally substituted by one or more substituents independently selected from halo, cyano, hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 haloalkyl, C 1-4 alkylOC(O), C 1-4 alkylOC 1-4 alkyl and C 1-4 alkylS(O) 2 and R x is hydrogen, or
A forms together with R x a 5 membered heterocyclic ring having one or more heteroatoms independently selected from O and N; and
R 5 and R 6 are independently selected from hydrogen, C 1-6 alkylC(O), NHR 7 C(O) and C 1-6 alkyl; and
R 7 is hydrogen, C 1-6 alkyl, C 1-6 alkylC(O)OC 1-3 alkyl, C 1-6 alkylC(O)O, C 1-6 alkylOC(O)C 1-3 alkyl, C 1-6 alkylOC(O), C 1-6 alkylC(O), C 5-10 heteroarylC 1-3 alkyl, C 5-10 heteroaryl, C 5-10 arylC 1-3 alkyl, C 5-10 aryl, C 3-6 cycloalkylC 1-3 alkyl or C 3-6 cycloalkyl.
7 . The compound according to claim 1 wherein R 3 is C 5-10 aryl, C 5-10 arylC 1-4 alkyl, C 5-10 arylO, C 5-10 arylOC 1-4 alkyl or C 5-10 heteroaryl, which may be optionally substituted by one or more substituents independently selected from B;
B is hydroxy, C 1-4 alkyl, C 1-4 alkoxy, C 1-4 alkylC 1-4 thioalkyl, C 1-4 thioalkyl, C 3-6 cycloalkylS, C 1-3 alkylS(O) n C 1-4 alkyl, C 1-3 alkylS(O) n , C 1-4 haloalkyl or halo; and
n is 1 or 2.
8 . The compound according to claim 1 wherein R 3 is phenyl substituted with one or more substituents independently selected from hydroxy, methoxy, ethoxy, methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, trifluoromethyl, fluoro, chloro, methylsulfanyl, ethylsulfanyl, cyclopropylsulfanyl, methylsulfanylethyl, ethylsulfanylmethyl, ethylsulfinylmethyl, methylsulfinylethyl or methylsulfonyl.
9 . The compound according to claim 1 wherein W is phenyl substituted with halo.
10 . The compound according to claim 1 wherein X is O.
11 . The compound according to claim 1 wherein Z is O.
12 . The compound according to claim 1 wherein R 1 is methyl.
13 . A compound selected from:
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclopropanecarboxamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]propanamide,
methyl N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]carbamate,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-hydroxy-2-methyl-propanamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]-2-methoxy-acetamide,
[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]carbamoylmethyl acetate,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfonylphenyl)propan-2-yl]-2-hydroxy-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methylsulfanylphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-ethylsulfanylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(4-cyclopropylsulfanylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide,
N-[(1R,2S)-1-(2,5-dioxabicyclo[4.4.0]deca-7,9,11-trien-8-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-naphthalen-2-yl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-naphthalen-2-yl-propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-(3-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(3-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-hydroxy-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-[4-(ethylsulfanylmethyl)phenyl]-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-[4-(ethylsulfinylmethyl)phenyl]-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-[4-(ethylsulfanylmethyl)phenyl]-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-hydroxy-acetamide,
4-amino-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]butanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-3-methoxy-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]benzamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-phenyl-acetamide,
[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]carbamoylmethyl acetate,
methyl[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]carbamoylformate,
[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]carbamoylformic acid,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-methyl-propanamide,
2-chloro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
2,2-dichloro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
2,2,2-trichloro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]butanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]cyclobutanecarboxamide,
2,2-difluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
2-fluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2-chloro-2-fluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
(2S)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-hydroxy-propanamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-hydroxyphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-acetamide,
N-[(1R,2S)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
N-[(1R,2S)-1-(4-ethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
2-fluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-methyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]cyclopentanecarboxamide,
(2R)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxy-propanamide,
(2S)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxy-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]propanamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2-hydroxy-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)-6-methyl-indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxy-acetamide,
2,2,2-trifluoro-N-[(2S,3S)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-yl]acetamide,
2,2,2-trifluoro-N-[(2R,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-yl]acetamide,
2,2,2-trifluoro-N-[(2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenoxy-butan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-(2-methoxyethoxy)acetamide,
2,2,2-trifluoro-N-[(2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenyl-butan-2-yl]acetamide,
N-[(2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenyl-butan-2-yl]-2,2-dimethyl-propanamide,
N-[(2S,3R)-3-[1-(4-fluorophenyl)indazol-5-yl]oxy-4-phenyl-butan-2-yl]-2-hydroxy-acetamide,
tert-butyl[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoylformate,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]oxamide,
propan-2-yl[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoylformate,
ethyl[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoylformate,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N′-methyl-oxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N′,N′-dimethyl-oxamide,
N′-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N-propan-2-yl-oxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-N′-tert-butyl-oxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4-(trifluoromethyl)benzamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]1,3-oxazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]1,3-oxazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]furan-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyrimidine-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyridine-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxyphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-pentan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-pentan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)pentan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)pentan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenyl-butan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)butan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)butan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2R)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-[6-chloro-1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-fluorophenyl)propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]sulfanyl-1-phenyl-propan-2-yl]acetamide,
1-(Cyclopentyl)-3-{(1S,2R)-2-[1-(4-fluorophenyl)-1H-indazole-5-yl)oxy]-1-methyl-2-phenyl-ethyl}urea,
1-{(1S,2R)-2-{[1-(4-Fluorophenyl)-1H-indazole-5-yl]oxy}-1-methyl-2-phenylethyl}-3-(2-furylmethyl)urea,
Ethyl N-{[(1S,2R)-2-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}-1-methyl-2-phenylethyl]carbamoyl}glycinate,
1-((R)-1,2-Dimethylpropyl)-3-{(1S,2R)-2-[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy]-1-methyl-2-phenylethyl}urea,
1-{(1S,2R)-2-{[1-(4-Fluorophenyl)-1H-indazole-5-yl]oxy}-1-methyl-2-phenylethyl}-3-(2-furylmethyl)thiourea,
N-{(1S)-1-[(R)-(3-Fluorophenyl)-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}methyl}-3-methyl-butyl}-2-methoxyacetamide,
2,2,2-Trifluoro-N-{(1S)-1-[(R)-(3-Fluorophenyl)-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}methyl}-3-methylbutyl}-acetamide,
N-[(1S)-(2R)-(3-Fluorophenyl)-2-{[1-(4-fluorophenyl)-1H-indazole-5-yl]oxy}-1-(methoxymethyl)ethyl]-2-methoxyacetamide,
N-[(1S)-(2R)-(3-Fluorophenyl)-2-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(methoxymethyl)ethyl]furan-2-carboxamide,
N-[(1S)-2-(3-Fluorophenyl)-2-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(hydroxymethyl)ethyl]-2-methoxyacetamide,
N-[(1S,2R)-1-Methyl-2-phenyl-2-{[1-(3-pyridyl)-1H-indazol-5-yl]oxy}ethyl]furan-2-carboxamide,
N-[(1S,2R)-1-Methyl-2-phenyl-2-{[1-(4-pyridyl)-1H-indazol-5-yl]oxy}ethyl]furan-2-carboxamide,
Methyl 4-(5-{(1R,2S)-2-[(2-furylcarbonyl)amino]-1-phenylpropoxy}-1H-indazol-1-yl)benzoate,
N-{(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-phenylpropan-2-yl}-5-methyl-[1,3,4]oxadiazol-2-carboxamide,
2-methoxy-N-[(1R,2S)-1-phenyl-1-(1-pyridin-2-ylindazol-5-yl)oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(6-chloropyridazin-3-yl)indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2,2,2-trifluoro-acetamide,
2-methoxy-N-[(1R,2S)-1-phenyl-1-(1-pyrimidin-2-ylindazol-5-yl)oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2-hydroxy-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-quinolin-3-yl-propan-2-yl]acetamide,
N-[(1R,2S)-1-(2,5-dioxabicyclo[4.4.0]deca-7,9,11-trien-8-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-hydroxy-acetamide,
N-[(1R,2S)-1-(2,5-dioxabicyclo[4.4.0]deca-7,9,11-trien-8-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
(2S)—N-[(1R,2S)-1-(2,5-dioxabicyclo[4.4.0]deca-7,9,11-trien-8-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]pyrrolidine-2-carboxamide,
N-[(1R,2S)-1-[1-(4-chlorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(2,5-dioxabicyclo[4.4.0]deca-7,9,11-trien-8-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
N-[(1R,2S)-1-[1-(4-chlorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-2,2-difluoro-propanamide,
2,2,2-trifluoro-N-[(1R,2S)-1-phenyl-1-(1-propan-2-ylindazol-5-yl)oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-(1-cyclopentylindazol-5-yl)oxy-1-phenyl-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-3-methyl-thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1-methyl-pyrrole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,2-oxazole-3-carboxamide,
N-[2-[1-(4-fluorophenyl)indazol-5-yl]oxy-2-phenyl-acetyl]-2-methyl-propanamide,
(2R)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxy-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-1-hydroxy-cyclopropane-1-carboxamide,
(2S)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-[4-(trifluoromethyl)phenyl]propan-2-yl]-2-hydroxy-propanamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-[4-(hydroxymethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-[4-(morpholin-4-ylmethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-[4-(dimethylaminomethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-[3-(hydroxymethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-[3-(morpholin-4-ylmethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-[3-(dimethylaminomethyl)phenyl]indazol-5-yl]oxy-1-phenyl-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2-dimethyl-N-[2,2,2-trifluoro-1-[[1-(4-fluorophenyl)indazol-5-yl]oxy-phenyl-methyl]ethyl]propanamide,
N-[(1S,2R)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(6-methoxypyridin-3-yl)propan-2-yl]cyclopropanecarboxamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethyl-phenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(3-chloro-5-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-tert-butylphenyl)propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-propylphenyl)propan-2-yl]acetamide,
N-[(1R,2S)-1-benzo[1,3]dioxol-5-yl-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(3-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-(4-chloro-3-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(4-chloro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(4-chloro-3-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethyl-phenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-chloro-5-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-tert-butylphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-propylphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-benzo[1,3]dioxol-5-yl-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(4-chloro-3-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethyl-phenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3-chloro-5-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-tert-butylphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-benzo[1,3]dioxol-5-yl-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethyl-phenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3-chloro-5-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-tert-butylphenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2-methoxyphenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
2,2-difluoro-N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
2,2-difluoro-N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
2,2-difluoro-N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
2,2-difluoro-N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
2,2-difluoro-N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
2,2-difluoro-N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]propanamide,
2,2-difluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-3,5-dimethyl-phenyl)propan-2-yl]propanamide,
N-[(1R,2S)-1-(4-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
N-[(1R,2S)-1-(3-chloro-5-fluoro-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
2,2-difluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methylphenyl)propan-2-yl]propanamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-2-methyl-propanamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-2-methyl-propanamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-fluoro-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(5-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
2-fluoro-N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methyl-propanamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(4-fluoro-2-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-3-hydroxy-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(3,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(3,4-difluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(3-fluoro-4-methyl-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(2,4-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
N-[(1R,2S)-1-(3-fluorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2-methoxy-acetamide,
2,2,2-trifluoro-N-[(1R,2S)-1-(3-fluoro-4-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]acetamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(4-methoxy-2-methyl-phenyl)propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[(1R,2S)-1-(2,5-dimethylphenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-difluoro-propanamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(2,4,5-trimethylphenyl)propan-2-yl]-2,2-dimethyl-propanamide,
N-[(1R,2S)-1-(5-fluoro-2-methoxy-phenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-1-methyl-cyclopropane-1-carboxamide,
N-[[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoylmethyl]acetamide,
2-(carbamoylamino)-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]acetamide,
3-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]imidazolidine-2,4-dione,
5-bromo-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methylsulfonyl-thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-2-carboxamide,
4-cyano-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-2-carboxamide,
5-bromo-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]furan-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3,4-oxadiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1H-imidazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1H-pyrazole-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]1,2-oxazole-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1H-1,2,4-triazole-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1H-pyrazole-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1-methyl-imidazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,2-oxazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1-methyl-triazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4,5-dimethyl-furan-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,5-dimethyl-pyrazole-3-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-methyl-1,3-thiazole-4-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4-methyl-1,3-thiazole-5-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4-methyl-1,3-thiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-4,5-dimethyl-thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-3-methoxy-thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1,9-diazabicyclo[4.3.0]nona-2,4,6,8-tetraene-8-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-1H-benzoimidazole-2-carboxamide,
5-chloro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]benzothiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]benzothiazole-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-3-hydroxy-5-(trifluoromethyl)thiophene-2-carboxamide,
N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]-5-(methoxymethyl)thiophene-2-carboxamide,
N-[(1R,2S)-1-(2-chlorophenyl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2-dimethyl-propanamide,
tert-butyl 3-[[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]carbamoyl]pyrrolidine-1-carboxylate,
2,2-difluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]propanamide,
(2R)-2-amino-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]propanamide,
(2R)—N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxyphenyl)propan-2-yl]pyrrolidine-2-carboxamide,
N-[(1S,2S)-3-(2,4-difluorophenoxy)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-methyl-propyl]-2,2,2-trifluoro-acetamide,
N-[(1S,2R)-2-(2,3-dihydrobenzofuran-6-yl)-2-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-methyl-ethyl]-2,2-difluoro-propanamide,
N-[(1R,2S)-1-(2,3-dihydrobenzofuran-6-yl)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-propan-2-yl]-2,2,2-trifluoro-acetamide, and
2,2,2-trifluoro-N-[(1R,2S)-1-[1-(4-fluorophenyl)indazol-5-yl]oxy-1-(3-methoxy-4-methylsulfanyl-phenyl)propan-2-yl]acetamide,
or a pharmaceutically acceptable salt thereof.
14 . A pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, according to claim 1 , and a pharmaceutically acceptable adjuvant, diluent or carrier.
15 . (canceled)
16 . (canceled)
17 . The method of claim 20 , wherein the method is a method of treating inflammatory conditions.
18 . The method of claim 20 , wherein the method is a method of treating asthma.
19 . The method of claim 20 , wherein the method is a method of treating COPD.
20 . A method of treating a glucocorticoid receptor mediated disease state, inflammatory conditions, asthma and/or COPD in a mammal, which comprises administering to a mammal in need of such treatment an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof, according to claim 1 .
21 . A combination of a compound of formula (I), or a pharmaceutically acceptable salt thereof, according to claim 1 , and one or more agents selected from the list comprising:
a PDE4 inhibitor;
a selective β.sub2. adrenoceptor agonist;
a muscarinic receptor antagonist;
a steroid;
a modulator of chemokine receptor function;
an inhibitor of p38 kinase function;
an inhibitor of matrix metalloproteases, most preferably targeting MMP-2, -9 or MMP-12; or
An inhibitor of neutrophil serine proteases, most preferably neutrophil elastase or proteinase 3.
22 . A process for the preparation of compounds of formula (I), according to claim 1 by coupling a compound of formula (II):
with acylation reagents of formula (IIIa) or formula (IIIb)
wherein R 1 , R 1a , R 2 , R 3 , R 4 , R 7 , A, W, X, Y and Z are defined as in claim 1 , and L 1 is a leaving group or, when L 1 =OH, a leaving group generated by reaction of a coupling reagent.
23 . A process for the preparation of compounds of formula (II), as defined in claim 22 , according to step a, b or c;
a) a compound of formula (II), wherein X is O, S or NH, may be prepared by coupling a compound of formula (IV)
wherein R 4 , W and Y are defined as in claim 1 and L 2 is a leaving group (such as halogen or triflate) with a compound of formula (V)
wherein R 1 , R 1a , R 2 and R 3 are defined as in claim 1 and G corresponds to R 3 or a protected precurser to R 3 ,
or,
b) a compound of formula (II) may be prepared by reacting a compound of formula (VII)
with a compound of formula (VIII)
wherein R 1 , R 2 , R 4 , R 3 , X, W and Y are defined as in claim 1 , G corresponds to R 3 or a protected precurser to R 3 and L 3 is a leaving group (such as halogen, mesylate or tosylate),
or,
c) a compound of formula (II) may be prepared by reacting a compound of formula (VIII) with a compound of formula (IX)
wherein R 1 , R 1a , R 2 and R 3 are defined as in claim 1 and PG is a suitable protecting group such as BOC, Ms, Ns, Ts or related carbonyl- or sulfonyl residues.