Compound and methods for its production
There is provided inter alia a compound of formula (I): for use in treatment of viral infection or as an immunosuppressant.
1. A compound of formula (I):
including any tautomer thereof; or an isomer thereof in which the C26, 27 C═C bond shown as trans is cis; and including a methanol adduct thereof in which a ketal is formed by the combination of the C-53 keto (if present) and the C-15 hydroxyl group and methanol;
or a pharmaceutically acceptable salt thereof.
2. A compound according to claim 1 is solid crystalline form.
3. A compound according to claim 2 in the form of its Form I crystalline polymorph.
4. A pharmaceutical composition comprising a compound according to claim 1 together with a pharmaceutically acceptable diluent or carrier.
5. A pharmaceutical composition comprising a compound according to claim 1 together with a pharmaceutically acceptable diluent or carrier further comprising a second or subsequent active ingredient.
6. A method of treating an HCV, HBV, or HIV infection, which comprises administering to a subject a therapeutically effective amount of a compound according to claim 1 .
7. A process for preparing a compound according to claim 1 which comprises reacting a compound of formula (V)
wherein each R 11 is independently C 1-4 alkyl or benzyl;
with an aldehydic macrocycle (compound of formula VI):
8. A process for the preparation of a compound of formula (I) in the form of its Form I crystalline polymorph according to claim 3 comprising the step of crystallising a compound of formula (I) from methyl isobutyl ketone.