Granted Patent
B2
US 9,207,243 · App. 13/435,625 · Granted Dec 8, 2015
Use of GLUT4 inhibitors and DNA damaging agents for treating multiple myeloma
Inventors:
Malathy Shanmugam (Lisle, IL); Samuel K. McBrayer (North Muskegon, MI); Steven T. Rosen (Evanston, IL)
Assignee:
Northwestern University
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Abstract
Methods of treating cancer comprising administering inhibitors of glucose transporters (GLUTs) are provided. Methods of predicting whether a cancer will respond to treatment with a GLUT inhibitor also are provided.
Claims (3)
1. A method of treating multiple myeloma in a patient having multiple myeloma, the method comprising:
(a) administering, a GLUT4 inhibitor to the patient, wherein the GLUT4 inhibitor inhibits glucose transport by GLUT4 and wherein the GLUT4 inhibitor is ritonavir; and (b) administering a DNA damaging agent to the patient, wherein the DNA damaging agent is doxorubicin.
2. The method of claim 1 , wherein the GLUT4 inhibitor is administered after the patient has fasted for at least 4 hours.
Assignments (2)
CONFIRMATORY LICENSE
Recorded Aug 19, 2013
From: NORTHWESTERN UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 031036/0061 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 11, 2012
From: SHANMUGAM, MALATHY; MCBRAYER, SAMUEL K.; ROSEN, STEVEN T.
To: NORTHWESTERN UNIVERSITY
Reel/Frame 028526/0979 →
Continuity (2)
Provisional Application
61470886
· Apr 1, 2011