IP Library › Granted Patent US 9,381,193
Granted Patent B2
US 9,381,193 · App. 13/436,469 · Granted Jul 5, 2016

Contraceptive methods and compositions

Inventors: Kelle H. Moley (St. Louis, MO); Antonina I. Frolova (St. Louis, MO)
Assignee: WASHINGTON UNIVERSITY
A61K31/455A61K31/5685A61K31/7008
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Quick Facts
Patent No.
US 9,381,193
App. No.
13/436,469
Granted
Jul 5, 2016
Kind
B2
Abstract

The invention encompasses compositions and methods for use in preventing pregnancy.

Claims (5)

1. A method of blocking decidualization of endometrial stromal cells in the uterus of a female mammal, the method comprising locally administering in the uterus an effective amount of an inhibitor of glucose-6-phosphate dehydrogenase, wherein the inhibitor is selected from the group consisting of dehydroepiandrosterone (DHEA)-sulfate, halogenated DHEA, and DHEA, and wherein the inhibitor of glucose-6-phosphate dehydrogenase blocks decidualization of the endometrial stromal cells in the uterus of the mammal.

2. The method of claim 1 , wherein the inhibitor is administered using an intrauterine device (IUD).

3. The method of claim 1 , wherein the inhibitor is administered in combination with other contraceptives.

4. The method of claim 1 , wherein the inhibitor is DHEA.

5. The method of claim 4 , wherein DHEA is administered using an intrauterine device (IUD).

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 31, 2017
From: WASHINGTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 042126/0136 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 2, 2012
From: MOLEY, KELLE; FROLOVA, ANTONINA
To: WASHINGTON UNIVERSITY
Reel/Frame 027970/0726 →
Continuity (2)
Provisional Application 61470925 · Apr 1, 2011
Related Publication 20130065853A1 · Mar 14, 2013