SYSTEMS AND METHODS FOR DE-RISKING PATIENT TREATMENT
The present disclosure describes systems and methods for de-risking patient treatment by identifying medications or combinations of medications to be contraindicated for a specific indication. An analyzer executed by a processor of a computing device from a user may receive an identification of an indication (e.g. the subject of a clinical trial, or the diagnosis of a patient visiting a physician's office). The analyzer may retrieve, from an adverse event database, medication and co-medication information of patients that experienced a side effect corresponding to the indication. The analyzer may sort the retrieved medication and co-medication information to generate an ordered list of medications consumed by patients that experienced the side effect, and identify a first medication of the ordered list. A display module executed by the computing device may display, to the user, the first medication of the ordered list for contraindication from the clinical trial.
1 . A method for identifying a medication for contraindication from an indication, comprising:
receiving, by an analyzer executed by a processor of a computing device from a user, an identification of an indication of a first patient;
retrieving, by the analyzer from an adverse event database, medication and co-medication information of patients that experienced a side effect corresponding to the indication;
sorting the retrieved medication and co-medication information, by the analyzer, to generate an ordered list of medications consumed by patients that experienced the side effect;
identifying, by the analyzer, a first medication of the ordered list; and
displaying, by a display module executed by the computing device to the user, the first medication of the ordered list for contraindication for the first patient.
2 . The method of claim 1 , further comprising determining, by the analyzer, that an organ is associated with the indication; and wherein retrieving medication and co-medication information of patients that experienced the side effect further comprises extracting a subset from the retrieved information of medications and co-medications identified as affecting the organ.
3 . The method of claim 1 , further comprising identifying, by the analyzer, a molecular interaction associated with the side effect; and identifying the first medication, responsive to the first medication identified in a medication information database as affecting the identified molecular interaction.
4 . The method of claim 1 , wherein identifying a first medication comprises determining a proportional reporting ratio of the first medication to all medications in the ordered list, and identifying the first medication, responsive to the proportional reporting ratio being above a predetermined threshold.
5 . The method of claim 1 , wherein sorting the retrieved medication and co-medication information comprises scoring each medication in the list responsive to its frequency of appearance in the retrieved medication and co-medication information, and sorting the list by score.
6 . The method of claim 1 , further comprising identifying, by the analyzer, a combination of a second medication and third medication appearing together in the retrieved medication and co-medication information at a statistical rate above a predetermined threshold; and displaying, by the display module, the combination of the second medication and third medication for contraindication from the clinical trial.
7 . A system for identifying a medication for contraindication from an indication, comprising:
a computing device comprising a processor executing
an analyzer configured for
receiving, from a user, an identification of an indication of a first patient,
retrieving, from an adverse event database, medication and co-medication information of patients that experienced a side effect corresponding to the indication,
sorting the retrieved medication and co-medication information to generate an ordered list of medications consumed by patients that experienced the side effect, and
identifying, by the analyzer, a first medication of the ordered list; and
a display module configured for displaying the first medication of the ordered list for contraindication from the first patient.
8 . The system of claim 7 , wherein the analyzer is further configured for determining that an organ is associated with the indication; and wherein retrieving medication and co-medication information of patients that experienced the side effect further comprises extracting a subset from the retrieved information of medications and co-medications identified as affecting the organ.
9 . The system of claim 7 , wherein the analyzer is further configured for identifying a molecular interaction associated with the side effect; and identifying the first medication, responsive to the first medication identified in a medication information database as affecting the identified molecular interaction.
10 . The system of claim 7 , wherein the analyzer is further configured for determining a proportional reporting ratio of the first medication to all medications in the ordered list, and identifying the first medication, responsive to the proportional reporting ratio being above a predetermined threshold.
11 . The system of claim 7 , wherein the analyzer is further configured for scoring each medication in the list responsive to its frequency of appearance in the retrieved medication and co-medication information, and sorting the list by score.
12 . The system of claim 7 , wherein the analyzer is further configured for identifying a combination of a second medication and third medication appearing together in the retrieved medication and co-medication information at a statistical rate above a predetermined threshold; and the display module is further configured for displaying the combination of the second medication and third medication for contraindication from the clinical trial.
13 . A computer readable storage device comprising computer-readable instructions for identifying a medication for contraindication from an indication, comprising:
instructions for receiving, by an analyzer executed by a processor of a computing device from a user, an identification of an indication of a first patient;
instructions for retrieving, by the analyzer from an adverse event database, medication and co-medication information of patients that experienced a side effect corresponding to the indication;
instructions for sorting the retrieved medication and co-medication information, by the analyzer, to generate an ordered list of medications consumed by patients that experienced the side effect;
instructions for identifying, by the analyzer, a first medication of the ordered list; and
instructions for displaying, by a display module executed by the computing device to the user, the first medication of the ordered list for contraindication from the first patient.
14 . The computer readable storage device of claim 13 , further comprising instructions for determining, by the analyzer, that an organ is associated with the indication; and wherein retrieving medication and co-medication information of patients that experienced the side effect further comprises extracting a subset from the retrieved information of medications and co-medications identified as affecting the organ.
15 . The computer readable storage device of claim 13 , further comprising instructions for identifying, by the analyzer, a molecular interaction associated with the side effect; and identifying the first medication, responsive to the first medication identified in a medication information database as affecting the identified molecular interaction.
16 . The computer readable storage device of claim 13 , further comprising instructions for determining a proportional reporting ratio of the first medication to all medications in the ordered list, and identifying the first medication, responsive to the proportional reporting ratio being above a predetermined threshold.
17 . The computer readable storage device of claim 13 , further comprising instructions for scoring each medication in the list responsive to its frequency of appearance in the retrieved medication and co-medication information, and sorting the list by score.
18 . The computer readable storage device of claim 13 , further comprising instructions for identifying, by the analyzer, a combination of a second medication and third medication appearing together in the retrieved medication and co-medication information at a statistical rate above a predetermined threshold; and displaying, by the display module, the combination of the second medication and third medication for contraindication from the clinical trial.