IP Library › Granted Patent US 8,388,930
Granted Patent B2
US 8,388,930 · App. 13/448,045 · Granted Mar 5, 2013

Diagnosis and assessment of skeletal related disease using calcium 41

Inventors: Darren J. Hillegonds (Oakland, CA); John S. Vogel (San Jose, CA); Robert L. Fitzgerald (Encinitas, CA); Leonard J. Deftos (Del Mar, CA); David Herold (Del Mar, CA); Douglas W. Burton (San Diego, CA)
Assignees: Lawrence LIvermore National Security, LLC; The Regents of the University of California
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Quick Facts
Patent No.
US 8,388,930
App. No.
13/448,045
Granted
Mar 5, 2013
Kind
B2
Abstract

A method of determining calcium metabolism in a patient comprises the steps of administering radioactive calcium isotope 41 Ca to the patient, allowing a period of time to elapse sufficient for dissemination and reaction of the radioactive calcium isotope 41 Ca by the patient, obtaining a sample of the radioactive calcium isotope 41 Ca from the patient, isolating the calcium content of the sample in a form suitable for precise measurement of isotopic calcium concentrations, and measuring the calcium content to determine parameters of calcium metabolism in the patient.

Claims (25)

1. A method of measuring calcium metabolism in a patient and obtaining information useful for determining the effect of drugs in the patient, comprising the steps of:

administering radioactive calcium isotope 41 Ca to the patient,

allowing a period of time to elapse sufficient for dissemination and reaction of said radioactive calcium isotope 41 Ca by the patient,

obtaining a sample of said radioactive calcium isotope 41 Ca from the patient,

isolating the calcium content of said sample in a form suitable for precise measurement of isotopic calcium concentrations,

measuring said isotopic calcium concentrations of said calcium thereby producing measurements of parameters of calcium metabolism, wherein said step of measuring said isotopic calcium concentrations to determine parameters of calcium metabolism in the patient comprises using decay counting to measure said radioactive calcium isotope 41 Ca to determine parameters of calcium metabolism in the patient, and

obtaining the information useful for determining the effect of drugs in the patient by comparing said measurements of parameters of calcium metabolism to a standard,

wherein said step of obtaining the information useful for determining the effect of drugs in the patient by comparing said measurements of parameters of calcium metabolism to a standard includes obtaining the information useful for determining the effect of drugs in the patient by comparing said measurements of parameters of calcium metabolism to a standard of parameters of calcium metabolism for average patients administered said drugs.

2. A method of monitoring the progression or therapeutic regression of a disease that modifies bone turnover rates in a patient, comprising the steps of:

administering a dose of radioactive calcium isotope 41 Ca to the patient at a time prior to the period in which the progression or therapeutic regression is to be observed,

allowing a period of time to elapse sufficient for dissemination and reaction of said radioactive calcium isotope 41 Ca by the patient,

collection of bodily fluids from the patient at regular intervals during said period of time wherein said step of collection of bodily fluids from the patient comprises collecting urine and sweat from the patient

isolating the calcium content of said urine and sweat samples in a form suitable for precise

measurement of isotopic calcium concentrations,

measuring said isotopic calcium concentrations of said calcium by an analytical system producing measurements,

comparing of said measurements to a standard, and

determination from said comparison any changes in the bone turnover rates within said period.

3. A method of monitoring the progression or therapeutic regression of a disease that modifies bone turnover rates in a patient, comprising the steps of:

administering a dose of radioactive calcium isotope 41 Ca to the patient at a time prior to the period in which the progression or therapeutic regression is to be observed,

allowing a period of time to elapse sufficient for dissemination and reaction of said radioactive calcium isotope 41 Ca by the patient,

collection of bodily fluids from the patient at regular intervals during said period of time wherein said step of collection comprises collecting sweat,

isolating the calcium content of said sweat sample in a form suitable for precise measurement of isotopic calcium concentrations,

measuring said isotopic calcium concentrations of said calcium by an analytical system producing measurements, wherein said step of measuring said calcium content by an analytical system comprises measuring said calcium content by decay counting,

comparing of said measurements to a standard, and

determination from said comparison any changes in the bone turnover rates within said period.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 4, 2014
From: HILLEGONDS, DARREN J.; VOGEL, JOHN S.; FITZGERALD, ROBERT L.; DEFTOS, LEONARD J.; HEROLD, DAVID; BURTON, DOUGLAS W.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 033026/0481 →
CONFIRMATORY LICENSE Recorded Feb 19, 2013
From: LAWRENCE LIVERMORE NATIONAL SECURITY, LLC
To: U.S. DEPARTMENT OF ENERGY
Reel/Frame 029834/0810 →
Continuity (3)
Continuation 11283034 · Nov 17, 2005
Provisional Application 60629354 · Nov 18, 2004
Related Publication 20120225486A1 · Sep 6, 2012