Calcium carbonate granulation
Highly compactable granulations and methods for preparing highly compactable granulations are disclosed. More particularly, highly compactable calcium carbonate granulations are disclosed. The granulations comprise powdered materials such as calcium carbonate that have small median particle sizes. The disclosed granulations are useful in pharmaceutical and nutraceutical tableting and provide smaller tablet sizes upon compression than previously available.
1. A calcium carbonate granulation for pharmaceutical or nutraceutical tabletting comprising: more than 90% by weight of a USP or food grade calcium carbonate powder having a median particle diameter from about 0.1 μm to about 20 μm and from about 2% to about 10% by weight maltodextrin having a dextrose equivalent (DE) of 10, said granulation being highly compactable and free flowing, having sufficient cohesive properties for compression into tablets, and having a tap density between about 0.9 and about 2.0 g/cm 3 .
2. A calcium carbonate granulation according to claim 1 , wherein the granulation has a tap density between about 1.0 and about 2.0 g/cm 3 .
3. A calcium carbonate granulation according to claim 2 , wherein the granulation has a tap density between about 1.1 and about 2.0 g/cm 3 .
4. A calcium carbonate granulation according to claim 3 , wherein the granulation has a tap density between about 1.25 and about 2.0 g/cm 3 .
5. A calcium carbonate granulation according to claim 1 , wherein said granulation has a water content of less than about 1% by weight.
6. A calcium carbonate granulation according to claim 1 , wherein said granulation comprises between about 2% and about 5% by weight maltodextrin.
7. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 0.1 μm to about 1 μm.
8. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 1 μm to about 3 μm.
9. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 3 μm to about 4 μm.
10. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 4 μm to about 6 μm.
11. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 6 μm to about 10 μm.
12. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 10 μm to about 12 μm.
13. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 12 μm to about 15 μm.
14. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle diameter from about 15 μm to about 20 μm.
15. A tablet comprising the calcium carbonate granulation of claim 1 .
16. A calcium carbonate granulation according to claim 1 , wherein said calcium carbonate powder has a median particle size of about 20 μm.
17. A tablet according to claim 15 , wherein said calcium carbonate powder has a median particle size of about 20 μm.