Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
1. A method of treating an ischemia reperfusion injury, said method comprising administering to a subject in need thereof an effective amount of a compound of formula
or pharmaceutically accept salt thereof,
wherein
said ischemia reperfusion injury is associated with stroke or acute head trauma.
2. The method according to claim 1 , wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.
3. The method according to claim 2 , wherein said compound is
4. A method of treating a neurologic disorder, said method comprising administering to a subject in need thereof an effective amount of a compound of formula
or pharmaceutically accept salt thereof,
wherein
said neurologic disorder is Parkinson's disease or amyotrophic lateral sclerosis (ALS).
5. The method according to claim 4 , wherein said neurologic disorder is associated with an over stimulation of an NMDA subtype of a glutamate receptor.
6. The method according to claim 5 , wherein said compound inhibits NMDA induced injury.
7. The method according to claim 4 , wherein said neurologic disorder is Parkinson's disease.
8. The method according to claim 4 , wherein said neurologic disorder is ALS.
9. The method according to claim 4 , wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.
10. The method according to claim 9 , wherein said compound is complexed with manganese.
11. The method according to claim 10 , wherein said compound is