Granted Patent
B2
US 9,051,615 · App. 13/462,300 · Granted Jun 9, 2015
Method of detecting and treating tuberous sclerosis complex associated disorders
Inventors:
Luca Rastelli (Guilford, CT); Bonnie Gould-Rothberg (Guilford, CT); Ryan Murphey (West Haven, CT)
Assignee:
Celldex Therapeutics, Inc.
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Abstract
Disclosed are methods of detecting and treating tuberous sclerosis complex associated disorders. Also disclosed are methods of identifying agents for treating tuberous sclerosis complex associated disorders.
Claims (5)
1. An isolated antibody that immunospecifically binds to an NMB polypeptide encoded by a nucleic acid of SEQ ID NO:26, wherein the NMB polypeptide comprises the amino acid sequence of SEQ ID NO:27.
2. The antibody of claim 1 , wherein the antibody is a monoclonal antibody.
3. The antibody of claim 1 , wherein the antibody is a human monoclonal antibody.
4. The antibody of claim 1 , wherein the antibody is a humanized antibody.
5. A pharmaceutical composition comprising the antibody of claim 1 and a carrier.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 9, 2014
From: RASTELLI, LUCA; GOULD-ROTHBERG, BONNIE; MURPHEY, RYAN
To: CURAGEN CORPORATION
Reel/Frame 033924/0208 →
MERGER AND CHANGE OF NAME
Recorded Oct 9, 2014
From: CURAGEN CORPORATION; CELLDEX THERAPEUTICS, INC.
To: CELLDEX THERAPEUTICS, INC.
Reel/Frame 033924/0250 →
Continuity (5)
Provisional Application
60254268
· Dec 8, 2000